Fitz9. Ch12: Soluble mediators

Question 1

Soluble polypeptide mediators for differentiation, growth, activation, migration

Answer 1

Cytokines

Question 2

Mediators of cellular trafficking

Answer 2

Chemokines

Question 3

Drug that targets JAK 1 and JAK 3 to treat psoriasis, alopecia, Dermatomyositis

Answer 3

TOFACITINIB

Question 4

Drug that targets JAK1 and JAK2 for dermatomyositis

Answer 4

RUXOLITINIB

Question 5

Drug targeting IL1Ra for adult rheumatic arthritis

Answer 5

ANAKINRA

Question 6

3 drugs that target TNF

Good for psoriasis, crohn, rheumatoid arthritis, psoriatic arthritis

Bad for multiple sclerosis, Tcell lymphoma, myco bacterial infections, tuberculosis

Answer 6

ADALIMUMAB, ETANERCEPT, INFLIXIMAB

Question 7

2 drugs targeting IL-17A for moderate to severe plaque psoriasis

Answer 7

SECUKINUMAB and IXEKIZUMAB

Question 8

Mediators for atopic immunity

Answer 8

Interleukin 4 and 13

Question 9

Interleukin important in asthma and allergies

Answer 9

Interleukin 9

Question 10

Interleukins with receptors using glycoprotein 130

Answer 10

IL-6 (psoriasis, kaposi sarcoma, lymphoma)
IL-11 (psoriasis)
IL-31 (atopic dermatitis)

Question 11

Targets Interleukin 12 and 23 to treat moderate to severe plaque psoriasis

Answer 11

USTEKINUMAB

Question 12

Is an anti-inflammatory cytokines whose Major source is epidermal keratinocytes

Answer 12

IL-10

Question 13

Interleukin that is both cationic and amphipathic and is used to treat irritant Bowel disease and rheumatic arthritis

Answer 13

Interleukin 26

Question 14

phosphodiesterase 4 inhibitor for treating moderate to severe plaque psoriasis

Answer 14

APREMALIST

Question 15

CCR5 inhibitor for treating HIV

Answer 15

MARAVIROC

Question 16

CXCR4 is.
CCR7 is.
CCR9 is.
CCR10 is.

Answer 16

CXCR4 is lungs.
CCR7 is lymph node.
CCR9 is small intestine.
CCR10 is metastasis.