Fitz9. Ch6: Skin Glands

Question 1

Human sebum contains (5)

Answer 1

TRIGLYCERIDES AND FFA, (Mc)
Wax esters 
Squalene, 
cholesterol esters
cholesterol

Question 2

Cells destined to be sebocytes have

Shh and Myc that is
Wnt that is

Answer 2

Sebocytes have

Shh and Myc: increased
Wnt decreased [increased in hair]

Question 3

Earliest known signal necessary for sebaceous gland development

Answer 3

SOX9

Question 4

Marker for terminal epithelial differentiation of sebaceous glands

Answer 4

PRDM1

Question 5

Loss of PRDM1 results in expression of

Answer 5

C-myc

Question 6

Major fatty acid in human sebum

Answer 6

Sapienic acid

Question 7

Average transit time of sebaceous gland cells from formation of discharge

Answer 7

7.4 days

Question 8

Most potent pharmacological inhibitor of sebum secretion

Answer 8

Isotretinoin

Question 9

Strongest stimulus for sweating

Answer 9

Hypothalamic temperature

Question 10

Major stimulus for eccrine sweat glands

Answer 10

Acetylcholine

Question 11

The secretory coil of eccrine sweat glands contain clear, dark and myoepithelial cell types. What is the difference between CLEAR Cells versus dark cells?

Answer 11

Clear cells are secretory cells that rest directly on basement membrane or myoepithelial cells. It has direct access to lumen; abundant mitochondria and lipofuscin in cytoplasm; secretes water and electrolytes

[dark/ mucous: border apical/ luminal ]

Question 12

After denervation of PREganglionic fibers, pharmacologic responsiveness of the sweat glands is maintained for how long

Answer 12

Months to years

Question 13

Major stimulator of sweat secretion

Answer 13

Periglandular acetylcholine

Question 14

Acclimatization lowers sweat ____ concentration

Answer 14

Lactate

Question 15

What are the 3 drugs secreted in sweat

Answer 15

griseofulvin
Ketoconazole
Amphetamines

Question 16

Ach induced sweating is mediated by

Answer 16

Intracellular calcium

Question 17

Adrenergic induced sweating is mediated by

Answer 17

Increase intracellular cAMP

Question 18

Cystic fibrosis, which has an increase in sweat concentration, have the following mutations

Answer 18

CFTR chloride channels and

Eccrine duct cL reabsorption

Question 19

Drugs that modify ductal NaCl reabsorption

Answer 19

Aldosterone
Topiramate (induces oligohidrosis)

Question 20

Mode of secretion for

Sebaceous glands
Apocrine glands

Answer 20

Sebaceous is Holocrine secretion while

Apocrine is merocrine secretion