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Jason's MD3 Women's > First Trimester Screening > Flashcards

First Trimester Screening Flashcards

1
Q

What to predict with first trimester screening?

A 
Trisomies
Preeclampsia
Fetal growth
Preterm
GDM
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2
Q

Prevalence in chromosomal abnormalities in order?

A

T21, T18, T13, Turners, sex trisomies

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3
Q

Maternal age a good population screen?

A

Not really, only detected 20% of T21 with amniocentesis

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4
Q

What is quadruple test in T2?detection rate?

A 
HCG
AFP
Unconjugated estriol
Inhibit-A
Detection is 75% for T21
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5
Q

Nuchal translucency threshold? Also detection rate?

A

Above 95centile, above 3mm

Detection: 80%

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6
Q

When can you measure Nuchal translucency?

A

11-13 weeks, when Crown rump length is between 45-84

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7
Q

T21 first trimester bio markers?

A

Free BHCG - High

PAPP-A - Low

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8
Q

T18 and T13 bio markers levels used with Nuchal translucency

A

Free BHCG - low

PAPP-A -Low

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9
Q

Detection rate of bio markers + Nuchal translucency?

A

90%

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10
Q

Adding nasal bone or tricuspid Regurg or ductus venosum to the bio markers plus Nuchal translucency?

A

96%

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11
Q

CVS, why sensitivity not 100%?

A

Placental mosaicism

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12
Q

Problems with microarray in 2016?

A

2% of population might have Variations of unknown significance detected. Can microarray parents to get an idea

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13
Q

Risk of amniocentesis/CVS for miscarriage for %?

A
  1. 1% -amnio

0. 2% - CVS

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14
Q

Fetal cell free DNA % in maternal circulation?

A

10% in maternal circulation

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15
Q

Meta-analysis of NIPT what is detection rate for trisomies?

A

T21: 99%, 0.08 false positive
T18: 96.8%
T13: 92.1

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16
Q

Problems with microdeletions In microarray?

A

Because they’re so rare, you’ll get more false positives

17
Q

NIPT probs for T21?

A

low fetal fraction in high BMI

Maternal age not factored in

18
Q

NIPT for sex chromosomes?

A

Not very good

19
Q

Nuchal translucency less than how many mm is good chance of normal preg?

A

Less than 3.4mm. 95% chance of normal

20
Q

Screening markers for early onset preeclampsia?

A

Hx+ Mean arterial BP + ultrasound uterine artery Doppler + PAPPA and Placental growth factor

21
Q

Preeclampsia detection, how to prevent?

A

Low-dose aspirin

22
Q

How does aspirin improve things in preg?

A

Improve trophoblast function, improve cytokines profile, and PLGF

Jason's MD3 Women's (58 decks)

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