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Infectious Agents II > Final Exam > Flashcards

Final Exam Flashcards

1
Q

What is the infectious particle for pythiosis?

A

Zoospore

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2
Q

What is the infectious particle for blastomycosis?

A

Microconidia

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3
Q

What is the infectious particle for zygomycetes?

A

Zygospore

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4
Q

What is the infectious particle for aspergillosis?

A

Conidia

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5
Q

What is the infectious particle for yeasts?

A

Chlamydoconidia

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6
Q

What is the infectious particle for dermatophytes?

A

Arthrospore

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7
Q

What is the infectivity of dimorphic fungi?

A

Highly infectious because of ability to adapt to unnatural environments once inhaled
This causes concern with presentation in necropsy

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8
Q

What are the primary forms of blastomycoses?

A 
Pulmonary form
Ocular form
Skin lesions
Bone
Genitourinary
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9
Q

Describe the pulmonary form of blastomycoses

A

Does not spontaneously resolve like histoplasmosis and coccidioidomycosis
Pulmonary mycoses have indicative “snowstorm” appearance on radiographs

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10
Q

Describe the ocular form of blastomycoses

A

Usually presents as uveitis

Sometimes panophthalmitis, glaucoma, acute retinal detachment (irreversible blindness)

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11
Q

Describe the skin lesions form of blastomycoses

A

Ulcerative or granulomatous dermatitis
Usually found in animal with pulmonary form- poor prognosis
More common on face, nose, lips, limbs, feet, pads, and toes

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12
Q

Describe the bone form of blastomycoses

A

See lameness and osteolytic lesions on long bones in radiographs

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13
Q

Describe the genitourinary form of blastomycoses

A

Signs like prostatitis- hematuria and pyuria

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14
Q

What is the best way to make a definitive diagnosis of any fungal disease?

A

Infections are diagnosed by demonstrating fungus in tissues (histo), exudates or aspirates (direct microscopy) or culturing
The most useful diagnostic tool is appearance in tissues and aspirates or exudates

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15
Q

Which agent makes a capsule?

A

Cryptococcous neoformans is an encapsulated yeast

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16
Q

Which agents exist in the GI tract of birds and bats?

A

Cryptococcus neoformans

Candida

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17
Q

What does Histomonas look like in situ?

A

It is not unusual to see 20 to 40 small yeast cells growing in a single host cell
Often, the cytoplasm has shrunk away from the cell wall and a clear area is evident between the 2 dark staining areas; thus, it appears to have a capsule

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18
Q

What are the geographic areas for Blastomyces dermatidis?

A

Major endemic areas: Mississippi, Ohio River basins, and central Atlantic states
Most common systemic mycosis in dogs in Louisiana, Arkansas, and Mississippi

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19
Q

What are the geographic areas for Histoplasma capsulatum?

A

Found worldwide
Major endemic areas: Eastern US, MS River Valley basin, Great Lakes, and Northeast US
Especially common in Kentucky and Indiana

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20
Q

What are the geographic areas for Coccidioides immitis?

A

Geographically limited to Southwestern states in US
Natural habitat- soil in semi-arid areas; high temp, low humidity
Highest endemicity found in California, Arizona, and West Texas along Mexican border
Also endemic in New Mexico, Nevada, and Utah

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21
Q

What are the geographic locations for Sporothrix schenckii?

A

Occurs in nature associated with soil, wood, and vegetation

Found worldwide, but more common in tropics and the South

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22
Q

What are the defining features of the class Zygomycota?

A

Coenocytic hyphae
Produce zygospores: single, dark, thick-walled, frequently ornamented sexual spore
In tissue, they are recognized by their broad,, aseptate, hyaline, randomly branched hyphal elements
2 orders: Mucorales and Entomophthales

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23
Q

What is unique to Mucorales with gross identification?

A

Fluffy, wooly, or cottony colonies: floccose aerial mycelium

Have “heads” (sporangia) near the edge

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24
Q

What is unique to Entromophthales with gross identification?

A

Translucent/opaque leather like, folded or wrinkled growth: compact, glabrous mycelium
These colonies have forcible ejected asexually produced spores

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25
What agents cause mycotic placentitis?
``` Mucor Mortierella Candida Aspergillus A variety of other molds ```
26
What causes zygomycosis?
Mucorales
27
What causes mycotic ruminitis in calves?
Absidia Rhizopus Mucor Rhizomucor
28
What causes mycotic placentitia in cows?
Mucor | Mortierella
29
What causes subcutaenous granulomas in dogs?
Absidia Cunninhhamella Syncephalastrum
30
What does Condidiobolus cornatus cause?
Sinusitis Nasopharyngitis Upper respiratory disease
31
What does Basidiobolus ranarum cuase?
Subcutaneous mycosis
32
Which agent is inhibited by cycloheximide?
Zygomycetes
33
Which agent is sensitive to cyclohemiide?
Cryptococcus
34
What is the diagnostic test for crypto?
Direct examination of smears from exudaes with India Ink will show yeasts cells surrounded by large capsule Culture can be done on blood agar or SDA, but inhibit by cylcoheximide Immunodiagnosis can be done by direct agglutination of circulating capsular antigen in a latex bead test
35
What are the reservoirs of Microsporum canis?
Zoophilic: animals are hosts and reservoirs
36
What are the reservoirs of Microsporum gypseum?
Geophilic: Soil is reservoir
37
What are the reservoirs of Trichophyton mentagrophytes?
Ubiquitous: found in many moist, dark, environemtns
38
What are the reservoirs of Epidermophyton flocculosum?
Anthropophilic: only found on humans
39
Which animals amplify Sporothrix so that when they introduce it back into the environment it causes false zoonosis?
Cats
40
What kind of tissues are invaded with dermatophytes?
Hair and skin
41
How far down do dermatophytes go into the hair follicle?
The grow down the side of the hair follicle and attach hair during anagen stage --> grow down to Adamson's fringe
42
Which dermatophytes occur in cattle?
Trichophyton verrucosum
43
Which dermatophytes occur in horses?
``` Microsporum canis M. gypseum Trichophyton metagrophytes T. equinum T. verrucosum ```
44
What is the result of sexual reproduction?
Spores
45
What is the result of asexual reproduction?
Conidia
46
What does teleomorph produce?
Meispore (spore formed via sexual reproduction resulting from meiosis; type of spore varies by phylum)
47
What does anamorph produce?
Mitospore (spore formed via asexual reproduction resulting from mitosis; commonly called a conidium or sporangiospore)
48
What class of Basidiomycetes are mushrooms and toadstools classified as?
Hymenomycetes
49
What is mushroom poisoning caused by?
Aminita Lepiota Coprinus Psilocybe
50
What is the quickest, easiest, and most reliable way to ID fungi?
Histopathology Cytology Culture
51
What dyes are used to stain dermatophytes?
PAS stain: hyphae stain bright red and are easily seen
52
What dyes are used to stain cryptococcus?
India ink will show yeast cells surrounded by a large capsule
53
What dyes are used to stain Blastomyces?
Stains can be used, but not usually necessary | Adding 10% KOH to specimen is helpful
54
What dyes are used to stain Histoplasma?
H&E can be used, but PAS is more specific of all fungi
55
What dyes are used to stain coccidioides?
10% KOH
56
What dyes are used to stain sporotrichosis?
PAS or methenamine silve stains
57
What is arthroconidium?
An asexual spore formed by the breaking up of a hypha at the point of septation The resulting cell may be recetangular or barrel shaped and thick or thin walled depending on genus
58
What is asexual reproduction?
Reproduction in an organism by division or redistribution of nuclei but without nuclear fusion (imperfect state)
59
What is blastoconidium?
Conidium formed by budding along hypha, pseudohypa, or single cell as in the yeasts
60
What is budding?
Process of asexual reproduction New cell develops as a smaller outgrowth from the older parent cell Characteristic of yeasts or yeast-like fungi
61
What is a capsule?
Colorless. transparent, nucopolysaccharide sheath on the wall of a cell
62
What is chlamydoconidium?
Conidium that is thick walled and contains stored food enabling it to function as a survival propagule It may be located at the end of the hypha (terminal) or inserted along the hypha (intercalary)- singly or in chains Greated in diameter than the hypha on which it is born Unlike other conidia, doesn't readily separate from the hypha
63
What is a germ tube?
Tubelike outgrowth from a conidium or spore- the beginning of a hypha
64
What is glabrous?
Smooth, without serial hyphae
65
What is a host?
Animal or plant that supports a parasite
66
What is hyaline?
Clear, transparent, colorless
67
What is a hypha?
Tubular or threadlike structure of a fungus | Many together compose mycelium
68
What is macroconidium?
Larger of the two type of conidia in fungi that produce both large and small conidia Usually multicelled, but can be single celled
69
What is microconidium?
Smaller of 2 types of conidia in fungi that produce both large and small conidia Usually single celled Usually round, ovoid, pear shaped, or club shaped
70
What is mold?
Fungus composed of filaments that generally form a colony that's fuzzy, powdery, woolly, velvety, or relatively smooth
71
What is monomorphic?
Fungi that have the same type of morph in culture at 25030 deg. C and 35-37
72
What is mycelium?
Mat of intertwined hyphae that constitutes the colony of a fungus
73
What is mycology?
Study of fungi
74
What is mycosis?
Disease produced by a fungus
75
What is pseudohyphae?
Chains of cells formed by budding that resemble true hyphae when elongated Differ from true hyphae because they are constricted at the septa forming branches that begin with a septation; also by having terminal cells smaller than the other cells
76
Do you culture a dimorph in a practice setting or in a lab?
No, you do not want to
77
Which fungi are dimorphs?
Blastomyces dermatidis Histoplasma capsulatum Coccidioides immitis Sporothrix schenchkii
78
What agents are associated with Nasopharangitis in the horse?
Condidiobolus cornatus typically infects mucocutaneous sites to produce sinusitis nasopharyngitis or upper respiratory disease in horses
79
What dermatophytes cause 99% of ringworm cases in dogs and cats?
``` Microsporum canis (98% in cats, 70% in dogs) M. gypseum (20% in dogs) Trichophyton mentagrophytes (10% in dogs) ```
80
What infection can dermatophytes cause?
Onychomycosis
81
What are cryptococcus infections most common in?
Cats
82
What tends to become involved with cryptococcus?
CNS | Eye involvement is common: chorioretinitis and blindness
83
What is the pathogenicity of cyptococcus often associated with?
The aniphagocytic and immunosuppressive capsule
84
What diseases are common with cryptococcus?
Mastitis characterized by gross swelling, induration, and gradual changes in secretions Ulcerative lesions of the nose, mouth, sinuses, and pharyn
85
What are the disease associations with Candidia?
Candidiasis (thrush) in birds Systemic candidiasis in feedlot cattle and piglets Cutaneous candidiasis in dogs and cats Opportunistic candidiasis in mastitis, abortion, and rumenitis
86
Describe candidiasis in birds
Lesions involve the mouth, crop, proventriculus, and gizzard- consisting of white circular patches or white elongated areas along the folds of mucosa. Epizootics in young birds have high mortality.
87
Describe systemic candidiasis in feedlot cattle
Dyspnea, pneumonia, nasal discharge, wasting
88
Describe systemic candidiasis in piglets
Pseudomembrane on the tongue, esophagus, and stomach causing vomiting and rapid wasting
89
What is the disease association with Malasseia pachydermitis?
Chronic otitis externa and pododermatitis of dogs
90
What are the disease associations with Aspergillis in avian species?
Diffuse infection of their air sacs Diffuse pneumonic form Nodular pneumonic form know as brooder pneumonia
91
What are the disease associations with Aspergillis in cattle?
Uterine, placental, or fetal skin infections may result in abortion Mastitis can occur by intra-mammary inoculation
92
What are the disease associations with Aspergillis in equine?
Abortions and gutteral pouch infection | Eye infections, keratomycosis can be very serious
93
What are the disease associations with Aspergillis in dogs?
Nasal aspergillosis Systemic aspergillosis caused by A. terris in Iga deficient GSD Osteomyelitis is a common finding
94
What are the disease associations with Aspergillis in penguins?
Pneumonia in captive birds housed inadequately
95
What can interal aspergillosis occur in?
Calves, foals, and cats
96
What is chytridiomycetes associated with?
Epidermal changes Morbidity and mortality in wild and captive anurans Cutaneous chytridiomycosis
97
What are the diseases associated with zygomycetes Conidiobolus and Basidiobolus??
Entomophthorales subcutaneous zygomycosis (Entomophthoromycosis)
98
What do mucorales cause?
subcutaneous and systemic zygomycosis (Mucormycosis)
99
What is Blastomycosis chronic disease characterized by?
Suppurative and granulomatous lesions
100
What is the primary site of Blastomycosis?
Lung. It can stay localized or disseminate to other organs
101
What are the disease ascscoations with histoplasmosis?
Most have slight or no clinical illness. Lesions don’t develop in the lung or intestine. Most common in people and dogs- occasionally cats. Primary site of infection- lung. GI form may develop too.
102
What are the disease associations with coccidiomycosis?
Mainly people dogs, and cats infected. Most virulent of all fungal pathogens. Benign, inapparent, or mildly severe URTI- usually resolves rapidly. Primary infection- 1-3 weeks after exposure. Rarely- disease is acute or chronic, severe, disseminating, fatal mycosis Most common in dogs involving bones, meninges, joints, subcutaneous, and cutaneous tissues Such involvement is characterized by burrowing abscesses May become characterized by formation of nodules or granulomas.
103
What is the disease associated with sporotrichosis?
Subacute or chronic disease in which lesions are confined to the skin and SQ tissues as nodules or granulomas- which may spread in a line along lymphatics and often ulcerate and srain (seropurulent) Most common in dog, cat, horse, and people. “Cigar bodies” in tissues
104
What does pythiosis cause?
Granulomatous inflammatory response
105
What are the characteristics of pythiosis?
Purulent outer coat of eosinophils and neutrophils forms around the developing and enlarging kunkers. Predominance of eosinophils in granulomas is the predominant histo characteristic.
106
What is the ingectious particle of pythium?
Zoospore
107
What does pythium do in the host? Know the pathogeneis and know the names associated with those structures
Pythium is in the water and reproduces asexually as zoospores. The zoospores (motile, biflagellated spores) are ingested by horse or dog. Zoospore comes into contact with mucosa of GI tract and can damage tissue or pass through mucosa and invade lymphatics. OR the zoospore can enter into a small cut/wound on limb of animal and invade the soft tissue. Once it germinates, it causes a granulomatous inflammatory response.
108
Which fungi get in the eyes of animals?
Pythium Blastomyces Aspergillis Cryptococcus
109
What is brooder pneumonia in chickens?
The nodular pneumonic form of aspergillosis
110
What is the mechanism of action of allyalimines (terbinafine)?
Inhibits ergosterol biosynthesis via inhibition of squalene epoxidase. Squalene eposidase is an enzyme part of the fungal sterol synthesis pathway that creates the need for sterols which are required for fungal cell membrane
111
What is the mechanism of antimetabolites (flucytosine)?
Inhibits fungal protein synthesis by replacing uracil with 5-flurouracil in fungal RNA. Also inhibits thymidylate synthetase which is a fancy way of saying it inhibits fungal DNA synthesis too.
112
What is the mechanism of action of azoles (fluconazole)?
It inhibits cytochrome P450 14a-demethylase (P45014DM) which is used in the sterol biosynthesis pathway and makes lanosterol to become ergosterol
113
What is the mechanism of actions of glucan synthesis inhibitors (capsofungin)?
Blocks synthesis of a major fungal cell wall component, 1-3-beta-D-glucan- this is really nice because animals do not have this receptor so little risk.
114
What is the mechanism of action of polyenes (amphotericin B)?
Binds to sterols (usually ergosterol) and disrupts osmotic integrity of the fungal membrane.
115
What is the mechanism of action of Griseofulvin?
Inhibits fungal mitosis by disrupting the mitotic spindle through interaction with polymerized microtubules
116
What is an example of allylamines?
Terbinafine
117
What is an example of antimetabolites?
Flucytosine
118
What are examples of azoles?
Fluconazole Ketoconazole Itraconazole
119
What are examples of glucan synthesis inhibitors?
Caspofungin Micafungin Anidulafungin
120
What is an example of polyenes?
Amphotericin B
121
What is an example of miscellaneous systemic agents?
Griseofulvin
122
What is the difference between fungi and pythiums?
Pythium cell membranes do not contain ergosterol, but its staining and morphology characteristics still resemble fungi.
123
What is the treatment of pythium?
Since Pythium does not share the same cell wall characteristics of fungi, antifungal chemotherapy agents do not work. Surgical removal of infected area is treatment of choice
124
Which fungal disease is associated with piglets?
Systemic candidiasis in piglets

Infectious Agents II (25 decks)

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