Exam 2: Herpesviridae Flashcards
Which herpesviruses have vaccines?
Bovine Herpesvirus Type 1, 2, 3 Porcine Herpesvirus- Psuedorabies Equine Herpesvirus type 1, 2, 3 Feline Herpesvirus Avian herpesvirus-Mareks Disease virus Herpes Zoster- Human herpesvirus
Which herpesviruses do not have vaccines?
Equine herpesvirus type 4
Herpes Simplex Virus Type 1 and 2 in humans/primates
Epstein Barr virus
Herpes simiae “B Virus”
What are the diseases caused by bovine herpesvirus type 1?
Infectious bovine rhinotracheitis
What are the forms of infectious bovine rhinotracheitis?
Encephalitis
Respiratory
Reproductive
What is the disease caused by bovine herpesvirus type 2?
Mammilitis
What is the disease caused by bovine herpesvirus type 3?
Malignant cararrhal fever, American and African forms
What species is pseudorabies found in?
Porcine
What disease is associated with pseudorabies virus?
Aujeszky’s disease
Describe Aujeszky’s disease (pseudorabies virus)
Swine, respiratory, fetal death, abortion, MUMMIES, high mortality in young
Highly fatal pruritis, paralysis in dogs, cats, ruminants, raccoons, rabbits, birds, but not in humans or horses
What is the disease associated with equine herpesvirus type 1?
Rhinopneumonitis, respiratory and reproductive
Describe the disease associated with equine herpesvirus type 2
Undetermined pathogenicity- pharyngitis of young horses
What is the disease associated with equine herpesvirus type 3?
Coitial exanthema
What is the disease associated with equine herpesvirus type 4?
Rhinopneumonitis, respiratory and reproductive
What is the disease associated with canine herpesvirus?
Fatal hemorrhagic disease in pups
What is the disease associated with Feline viral rhinotracheitis virus, feline herpesvirus 1?
Upper respiratory tract disease
What is the disease associated with feline urolithiasis virus, feline herpes virus 2?
Experimental disease, urolithiasis resulting in uremia
What is the disease associated with infectious laryngotracheitis virus (avian)?
Upper respiratory tract disease
What are the diseases associated with Marek’s disease virus?
Oncogenic, neural, ocular, and visceral lymphomatosis
What are the diseases associated with duck plague virus?
Enteric. respiratory, CNS
What are the diseases associated with herpesvirus infection of pigeons?
Coryza, laryngeal and pharyngeal ulcers
What is the disease associated with herpes simplex virus type 1?
Oral blisters
What is the disease associated with herpes simplex virus type 2?
Genital blisters
What diseases are associated with herpes zoster?
Chicken pox, shingles
What diseases are associated with Epestein Barr Virus?
Mononucleosis, chronic fatigue syndrome, oncogenic
What are the diseases associated with Herpes simiae, “B” virus?
Old world monkeys: epithelial barriers
Humans: fatal encephalitis
What is the disease associated with channel catfish virus?
Mortality in young fish
What are the oncogenic herpesviruses?
Marek’s Disease Virus
Epstein Barr virus
Which herpesviruses are reportable?
African form of malignant catarrhal fever Pseudorabies virus Marek's Disease Virus Herpes Simplex Virus type 2 Herpes simiae, B virus
Why should MLV vaccines of herpesviruses not be used in pregnant animals?
It can cause abortion
What is the latency of alphaherpesviridae?
Frequent, but not exclusively in ganglia
What is the latency of betaherpeviridae?
In epithelial cells of secretory glands, RES, kidney, salivary, and adrenal glands
What is the latency of gammaherpeviridae?
Frequent in B and T cells
What are the 3 mechanisms of latency?
Episome formation
Insertion into host chromosome
Primary infection by herpes simplex virus type 1
What is needed for pathogenicity to occur in episome formation?
Thymidine kinase gene
What is insertion into the host chromosome?
Insertion may occur at the germ line and result in somatic cell oncogenesis and teratogenesis
Requires a restriction endonuclease enzyme that leaves DNA at palindromic sequences exposing “sticky ends”
What are latency-associated transcript (LAT) and latency-related (LR) RNA?
Involved in the primary infection HSV-1 latency mechanism
Antigesense to viral genes that are crucial for productive infection
What is latency-associated transcript important for?
The latency reactivation cycle
What is the latency-related RNA gene required for?
The latency-reactivation cycle in cattle
What are the types of herpesvirus infections?
Fetal/vertical infections
Congenital infections (trans-ovarian, morula infection, semen)
Transplacental infections
