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Infectious Agents II > Exam 2: Herpesviridae > Flashcards

Exam 2: Herpesviridae Flashcards

1
Q

Which herpesviruses have vaccines?

A 
Bovine Herpesvirus Type 1, 2, 3
Porcine Herpesvirus- Psuedorabies
Equine Herpesvirus type 1, 2, 3 
Feline Herpesvirus
Avian herpesvirus-Mareks Disease virus
Herpes Zoster- Human herpesvirus
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2
Q

Which herpesviruses do not have vaccines?

A

Equine herpesvirus type 4
Herpes Simplex Virus Type 1 and 2 in humans/primates
Epstein Barr virus
Herpes simiae “B Virus”

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3
Q

What are the diseases caused by bovine herpesvirus type 1?

A

Infectious bovine rhinotracheitis

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4
Q

What are the forms of infectious bovine rhinotracheitis?

A

Encephalitis
Respiratory
Reproductive

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5
Q

What is the disease caused by bovine herpesvirus type 2?

A

Mammilitis

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6
Q

What is the disease caused by bovine herpesvirus type 3?

A

Malignant cararrhal fever, American and African forms

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7
Q

What species is pseudorabies found in?

A

Porcine

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8
Q

What disease is associated with pseudorabies virus?

A

Aujeszky’s disease

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9
Q

Describe Aujeszky’s disease (pseudorabies virus)

A

Swine, respiratory, fetal death, abortion, MUMMIES, high mortality in young
Highly fatal pruritis, paralysis in dogs, cats, ruminants, raccoons, rabbits, birds, but not in humans or horses

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10
Q

What is the disease associated with equine herpesvirus type 1?

A

Rhinopneumonitis, respiratory and reproductive

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11
Q

Describe the disease associated with equine herpesvirus type 2

A

Undetermined pathogenicity- pharyngitis of young horses

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12
Q

What is the disease associated with equine herpesvirus type 3?

A

Coitial exanthema

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13
Q

What is the disease associated with equine herpesvirus type 4?

A

Rhinopneumonitis, respiratory and reproductive

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14
Q

What is the disease associated with canine herpesvirus?

A

Fatal hemorrhagic disease in pups

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15
Q

What is the disease associated with Feline viral rhinotracheitis virus, feline herpesvirus 1?

A

Upper respiratory tract disease

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16
Q

What is the disease associated with feline urolithiasis virus, feline herpes virus 2?

A

Experimental disease, urolithiasis resulting in uremia

17
Q

What is the disease associated with infectious laryngotracheitis virus (avian)?

A

Upper respiratory tract disease

18
Q

What are the diseases associated with Marek’s disease virus?

A

Oncogenic, neural, ocular, and visceral lymphomatosis

19
Q

What are the diseases associated with duck plague virus?

A

Enteric. respiratory, CNS

20
Q

What are the diseases associated with herpesvirus infection of pigeons?

A

Coryza, laryngeal and pharyngeal ulcers

21
Q

What is the disease associated with herpes simplex virus type 1?

A

Oral blisters

22
Q

What is the disease associated with herpes simplex virus type 2?

A

Genital blisters

23
Q

What diseases are associated with herpes zoster?

A

Chicken pox, shingles

24
Q

What diseases are associated with Epestein Barr Virus?

A

Mononucleosis, chronic fatigue syndrome, oncogenic

25
Q

What are the diseases associated with Herpes simiae, “B” virus?

A

Old world monkeys: epithelial barriers

Humans: fatal encephalitis

26
Q

What is the disease associated with channel catfish virus?

A

Mortality in young fish

27
Q

What are the oncogenic herpesviruses?

A

Marek’s Disease Virus

Epstein Barr virus

28
Q

Which herpesviruses are reportable?

A 
African form of malignant catarrhal fever
Pseudorabies virus
Marek's Disease Virus
Herpes Simplex Virus type 2
Herpes simiae, B virus
29
Q

Why should MLV vaccines of herpesviruses not be used in pregnant animals?

A

It can cause abortion

30
Q

What is the latency of alphaherpesviridae?

A

Frequent, but not exclusively in ganglia

31
Q

What is the latency of betaherpeviridae?

A

In epithelial cells of secretory glands, RES, kidney, salivary, and adrenal glands

32
Q

What is the latency of gammaherpeviridae?

A

Frequent in B and T cells

33
Q

What are the 3 mechanisms of latency?

A

Episome formation
Insertion into host chromosome
Primary infection by herpes simplex virus type 1

34
Q

What is needed for pathogenicity to occur in episome formation?

A

Thymidine kinase gene

35
Q

What is insertion into the host chromosome?

A

Insertion may occur at the germ line and result in somatic cell oncogenesis and teratogenesis
Requires a restriction endonuclease enzyme that leaves DNA at palindromic sequences exposing “sticky ends”

36
Q

What are latency-associated transcript (LAT) and latency-related (LR) RNA?

A

Involved in the primary infection HSV-1 latency mechanism

Antigesense to viral genes that are crucial for productive infection

37
Q

What is latency-associated transcript important for?

A

The latency reactivation cycle

38
Q

What is the latency-related RNA gene required for?

A

The latency-reactivation cycle in cattle

39
Q

What are the types of herpesvirus infections?

A

Fetal/vertical infections
Congenital infections (trans-ovarian, morula infection, semen)
Transplacental infections

Infectious Agents II (25 decks)

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