Exam 2: Adenoviridae

Question 1

What is the specificity of adenovirus?

Answer 1

Highly host specific

Question 2

What is adenovirus isolated from?

Answer 2

Humans, animals, and birds, usually from the upper respiratory tract

Question 3

What are the characteristics of Adenovirus?

Answer 3

Linear dsDNA, 30-37 kbp in size

Icosahedral virion, 70-90 nm

Question 4

Where does Adenovirus replicate?

Answer 4

Nucleus of cells

Question 5

Where are Adenovirus virions released by?

Answer 5

Cell lysis

Question 6

What does adenovirus produce?

Answer 6

Intranuclear inclusion bodies containing virions

Question 7

How do many adenoviruses agglutinate RBCs?

Answer 7

The tips of the fiber bind to a receptor on the surface of the RBC

Question 8

What is the classification of adenovirus based on?

Answer 8

Antigenic relationships

Question 9

What are the 2 genera of adenovirus?

Answer 9

Mastadenovirus (mammalian adenoviruses)

Aviadenoviruses (avian adenoviruses)

Question 10

What is located on the pentamers of adenovirus?

Answer 10

Genus-specific antigenic determinants

Question 11

What is located of the hexamers and fibers of adenovirus?

Answer 11

Type-specific antigenic determinants

Question 12

What does adenovirus usually cause?

Answer 12

Acute, mild, or subclinical respiratory disease

Question 13

What is adenovirus usually confined to?

Answer 13

Upper respiratory tract, but may include conjunctivitis and bronchopneumonia

Question 14

What can adenoviruses often be recovered from?

Answer 14

The lymphoid organs of healthy animals

Question 15

What does adenovirus cause in horses?

Answer 15

Generalized infections in certain Arabian foals with primary severe combined immunodeficiency

Question 16

When do generalized infections from adenovirus occur in avian species?

Answer 16

When immune systems are compromised by avian leukosis, infectious bursal disease or chicken anemia

Question 17

What may canine adenovirus 1 cause?

Answer 17

Repsiratory or ocular disease, encephalopathy, chronic hepatitis, and nephritis

Question 18

What are canine adenovirus 1 and 2 related to?

Answer 18

Kennel cough

Question 19

What does canine adenovirus 2 cause?

Answer 19

Respiratory disease

Question 20

What is canine adenovirus 1 the main cause of?

Answer 20

Infectious canine hepatitis

Question 21

What are the signs of infectious canine hepatitis?

Answer 21

Increase thirst
Anorexia
Tonsilitis
Petechial hemorrhage on the mucous membranes
Diarrhea

Question 22

What is severe infectious canine hepatitis most likely to occur in?

Answer 22

Pups that are not immune to the disease

Question 23

What is blue eye?

Answer 23

Caused by canine adenovirus 1

Results from corneal edema

Question 24

What are the vaccines used for canine adenovirus 1?

Answer 24

Both killed and attenuated live

Question 25

What vaccine is used for canine adenovirus 2?

Answer 25

Attenuated live

Question 26

Can the canine adenovirus 2 vaccine cross-protect?

Answer 26

Yes and it does not cause corneal edema

Question 27

What is canine adenovirus confirmed by?

Answer 27

Serologic testing

Question 28

What is canine adenovirus 2 isolated from?

Answer 28

Acute cough

Question 29

What is canine adenovirus 2 one of several infectious agents implicated in?

Answer 29

Kennel cough

Question 30

Does canine adenovirus 2 produce renal and ocular lesions?

Answer 30

No

Question 31

What are the serotypes that are more pathogenic in bovine adenoviruses?

Answer 31

BAV 3 and BAV 5

Question 32

What is the main pathogen of equine adenovirus infections?

Answer 32

Adenovirus type 1

Question 33

What are group 1 avian adenovirus infections?

Answer 33

Share a common group antigen and have been isolated from chickens, turkeys, geese, and other species

Question 34

What are group 2 avian adenovirus infections?

Answer 34

Share a different group antigen and include viruses from turkey hemorrhagic enteritis, marble spleen disease, and splenomegaly in chicken

Question 35

What are group 3 avian adenovirus infecitons?

Answer 35

Partially antigenically related to group 1 viruses and associated with egg drop syndrome in chickens and ducks

Question 36

What does avian adenoviruses cause subclinical infections in?

Answer 36

Breeding flocks and contaminate eggs

Question 37

What is used in the production of a vaccine for avian adenoviruses?

Answer 37

Chicken embryos origin egg cell cultures as a substrate

Question 38

What are adenovirus contaminated cells used to produce?

Answer 38

Avian live-virus vaccine