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Infectious Agents II > Exam 2: Adenoviridae > Flashcards

Exam 2: Adenoviridae Flashcards

1
Q

What is the specificity of adenovirus?

A

Highly host specific

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2
Q

What is adenovirus isolated from?

A

Humans, animals, and birds, usually from the upper respiratory tract

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3
Q

What are the characteristics of Adenovirus?

A

Linear dsDNA, 30-37 kbp in size

Icosahedral virion, 70-90 nm

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4
Q

Where does Adenovirus replicate?

A

Nucleus of cells

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5
Q

Where are Adenovirus virions released by?

A

Cell lysis

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6
Q

What does adenovirus produce?

A

Intranuclear inclusion bodies containing virions

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7
Q

How do many adenoviruses agglutinate RBCs?

A

The tips of the fiber bind to a receptor on the surface of the RBC

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8
Q

What is the classification of adenovirus based on?

A

Antigenic relationships

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9
Q

What are the 2 genera of adenovirus?

A

Mastadenovirus (mammalian adenoviruses)

Aviadenoviruses (avian adenoviruses)

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10
Q

What is located on the pentamers of adenovirus?

A

Genus-specific antigenic determinants

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11
Q

What is located of the hexamers and fibers of adenovirus?

A

Type-specific antigenic determinants

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12
Q

What does adenovirus usually cause?

A

Acute, mild, or subclinical respiratory disease

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13
Q

What is adenovirus usually confined to?

A

Upper respiratory tract, but may include conjunctivitis and bronchopneumonia

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14
Q

What can adenoviruses often be recovered from?

A

The lymphoid organs of healthy animals

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15
Q

What does adenovirus cause in horses?

A

Generalized infections in certain Arabian foals with primary severe combined immunodeficiency

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16
Q

When do generalized infections from adenovirus occur in avian species?

A

When immune systems are compromised by avian leukosis, infectious bursal disease or chicken anemia

17
Q

What may canine adenovirus 1 cause?

A

Repsiratory or ocular disease, encephalopathy, chronic hepatitis, and nephritis

18
Q

What are canine adenovirus 1 and 2 related to?

A

Kennel cough

19
Q

What does canine adenovirus 2 cause?

A

Respiratory disease

20
Q

What is canine adenovirus 1 the main cause of?

A

Infectious canine hepatitis

21
Q

What are the signs of infectious canine hepatitis?

A 
Increase thirst
Anorexia
Tonsilitis
Petechial hemorrhage on the mucous membranes
Diarrhea
22
Q

What is severe infectious canine hepatitis most likely to occur in?

A

Pups that are not immune to the disease

23
Q

What is blue eye?

A

Caused by canine adenovirus 1

Results from corneal edema

24
Q

What are the vaccines used for canine adenovirus 1?

A

Both killed and attenuated live

25
Q

What vaccine is used for canine adenovirus 2?

A

Attenuated live

26
Q

Can the canine adenovirus 2 vaccine cross-protect?

A

Yes and it does not cause corneal edema

27
Q

What is canine adenovirus confirmed by?

A

Serologic testing

28
Q

What is canine adenovirus 2 isolated from?

A

Acute cough

29
Q

What is canine adenovirus 2 one of several infectious agents implicated in?

A

Kennel cough

30
Q

Does canine adenovirus 2 produce renal and ocular lesions?

A

No

31
Q

What are the serotypes that are more pathogenic in bovine adenoviruses?

A

BAV 3 and BAV 5

32
Q

What is the main pathogen of equine adenovirus infections?

A

Adenovirus type 1

33
Q

What are group 1 avian adenovirus infections?

A

Share a common group antigen and have been isolated from chickens, turkeys, geese, and other species

34
Q

What are group 2 avian adenovirus infections?

A

Share a different group antigen and include viruses from turkey hemorrhagic enteritis, marble spleen disease, and splenomegaly in chicken

35
Q

What are group 3 avian adenovirus infecitons?

A

Partially antigenically related to group 1 viruses and associated with egg drop syndrome in chickens and ducks

36
Q

What does avian adenoviruses cause subclinical infections in?

A

Breeding flocks and contaminate eggs

37
Q

What is used in the production of a vaccine for avian adenoviruses?

A

Chicken embryos origin egg cell cultures as a substrate

38
Q

What are adenovirus contaminated cells used to produce?

A

Avian live-virus vaccine

Infectious Agents II (25 decks)

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