Exam 1: Intro to Virology Flashcards

1
Q

Describe the important dates in virology history

A

1796, May 14: Edward Jenner uses cowpox from the milkmaid Sarrah Nemes to vaccinate 8 year old James Phipps against small pox

1970: David Baltimore and Howard Temin discover reverse transcriptase and retroviruses
1980: Small pox eradicated
1983: HIV defined as the cause of AIDS

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2
Q

What is arbovirus?

A

Older term for arthropod-borne viruses, however many viruses transmitted by insects are not considered arboviruses

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3
Q

What is bacteriophage?

A

A virus parasitizing bacteria
There are 10 phages per bacteria
Most numerous biological entity today

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4
Q

What is capsid?

A

Protein coat of a virus

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5
Q

What is capsomere?

A

Individual structure proteins that collectively make up the capsid

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6
Q

What is defective interfering particle?

A

A virus particle having a capsid, but an incomplete nucleic acid content, or an empty particle, which interferes with replication of complete particles

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7
Q

What is an envelope?

A

The phospholipid covering derived from host cell membranes, either nuclear or cytoplasmic, present on some viruses

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8
Q

What is icosahedron?

A

Polyhedral shape composed of 12 vertices and 20 triangular faces
Icosahedron nucleocapsids are of cubic symmetry

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9
Q

What is an orphan virus?

A

A virus isolated in the absence of disease

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10
Q

What is peplomere?

A

Glycoprotein subunit projecting from envelope referred to as “spikes” that function in attachment to host cells

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11
Q

What are prions?

A

Unconventional agents of disease resulting in spongiform encephalopathies by proteins that cause protein folding anomalies

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12
Q

What is translation?

A

Process by which base sequences in mRNA produce specific amino acid sequences in a protein

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13
Q

What is transcription?

A

Process of forming mRNA from nucleic acid, not necessarily DNA

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14
Q

What is a virion?

A

An individual viral particle

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15
Q

What are viroids?

A

A class of infectious agents, occurring in plant that are smaller than viruses and consist of short strands of RNA without a capsid

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16
Q

What is a virus?

A

A complex molecular particle, capable of infecting cells and causing disease by redirecting host cellular synthetic machinery towards the synthesis of new infectious particles
It is composed of nucleic acid (DNA or RNA, but not both), proteins, and sometimes lipids and carbs in the form glycoproteins

17
Q

What are the 2 ways that viruses are responsible for evolution?

A

Move genes around

Certain immune systems survive and reproduce

18
Q

What is the replication site of DNA virus Pox? Enzyme?

A

Cytoplasm

DNA dependent, RNA polymerase- DNA dependent, DNA polymerase coded for by virus

19
Q

What is the replication site of DNA virus herpes? Enzyme?

A

Nucleus

DNA dependent, RNA polymerase- DNA dependent, DNA polymerase coded for by host cell

20
Q

What is the replication site of DNA virus adeno? Enzyme?

A

Nucleus

DNA dependent, RNA polymerase- DNA dependent, DNA polymerase coded for by host cell

21
Q

What is the replication site of DNA virus papova? Enzyme?

A

Nucleus

DNA dependent, RNA polymerase- DNA dependent, DNA polymerase coded for by host cell

22
Q

What is the replication site of DNA virus parvo? Enzyme?

A

Nucleus

DNA dependent, RNA polymerase- DNA dependent, DNA polymerase coded for by host cell

23
Q

What is the replication site of DNA virus asfar? Enzyme?

A

Nucleus

DNA dependent, RNA polymerase- DNA dependent, DNA polymerase coded for by virus

24
Q

What is the replication site of DNA virus irido? Enzyme?

A

Nucleus

DNA dependent, RNA polymerase- DNA dependent, DNA polymerase coded for by virus

25
Q

What is the replication site of DNA virus hepadna? Enzyme?

A

Nucleus

DNA dependent, RNA polymerase- DNA dependent, DNA polymerase coded for by virus

26
Q

What is the replication site of DNA virus circo? Enzyme?

A

Nucleus

DNA dependent, RNA polymerase- DNA dependent, DNA polymerase coded for by virus

27
Q

What is the replication site for RNA virus picorna? Enzyme?

A

Cytoplasm

RNA dependent, RNA polymerase coded for by virus

28
Q

What is the replication site for RNA virus toga? Enzyme?

A

Cytoplasm

RNA dependent, RNA polymerase coded for by virus

29
Q

What is the replication site for RNA virus bunya? Enzyme?

A

Cytoplasm

RNA dependent, RNA polymerase carried by virus

30
Q

What is the replication site for RNA virus corona? Enzyme?

A

Cytoplasm

RNA dependent, RNA polymerase coded for by virus

31
Q

What is the replication site for RNA virus orthomyxo? Enzyme?

A

Cytoplasm

RNA dependent, RNA polymerase carried by virus

32
Q

What is the replication site for RNA virus paramyxo? Enzyme?

A

Nucleus

RNA dependent, RNA polymerase carried by virus

33
Q

What is the replication site for RNA virus rhabdo? Enzyme?

A

Cytoplasm

RNA dependent, RNA polymerase carried by virus

34
Q

What is the replication site for RNA virus reo? Enzyme?

A

Cytoplasm

RNA dependent, RNA polymerase carried by virus

35
Q

What is the replication site for RNA virus retro? Enzyme?

A

Nucleus
RNA dependent, DNA polymerase carried by virus
Carry and code for Reverse Transcriptase

36
Q

What is the replication site for RNA virus arena? Enzyme?

A

Cytoplasm

RNA dependent, RNA polymerase carried by virus

37
Q

What is the replication site for RNA virus calici? Enzyme?

A

Cytoplasm

RNA dependent, RNA polymerase coded for by virus

38
Q

What must a RNA dependent, RNA polymerase virus have since they are negative sense?

A

A RNA dependent polymerase riding with negative sense to convert it to a positive messenger so that proteins can be produced