Exam 3: Rabies Flashcards
What is rabies virus?
A Lyssavirus that has linear single-stranded RNA of negative sense
What is the genome of rabies?
12 kilobases in size and codes 5 proteins
What is the rabies virus particle like?
Helical and enveloped
What is the rabies RR transcriptase carried by?
Virus
Where does rabies replicate?
In cytoplasm of host neuronal cell
Is rabies a cytocidal virus?
No, it is a persistent virus that disrupts neuronal function
How many proteins does rabies virus code for?
5
What species can acquire sylavtic rabies?
Foxes (North East and West Texas) Skunks (Midwest) Raccoons (GA and FL, North East) Bats (pan-continental) Coyotes (Southwest Texas)
What species can acquire street rabies?
Dogs and cats, but there are no street rabies in the US due to vaccines
What species can acquire fixed viruses?
Cell, egg, and lab animal cultures
What animals are more susceptible to rabies?
Warm blooded animals
What animals are resistant to rabies?
Birds
Guinea pigs
Opossums
What are the serotypes of vesicular stomatitis virus?
Indiana and New Jersey serotypes
What are the serotypes of vesicular stomatitis virus named after?
States they haven’t been found in
What is the disease associated with Rabies?
Zoonotic, CNS