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Systems Path 2 > Final: Blood Cells Cont. > Flashcards

Final: Blood Cells Cont. Flashcards

1
Q

Leukemia location

A

Marrow or blood

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2
Q

Lymphoma location

A

Lymphatic tissue

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3
Q

Anemia is the MC initial feature of

A

Acute leukemia

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4
Q

2 types of acute leukemia’s

A

Acute lymphoblastic leukemia

Acute myeloid leukemia

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5
Q

Sudden and “stormy” onset are indicative of

A

Acute leukemia

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6
Q

MC pediatric cancer

A

Acute lymphoblastic leukemia

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7
Q

ALL MC diagnosed at

A

Age 3, later with T cell age 15

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8
Q

Prognosis of ALL

A

80% cure rate

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9
Q

Aggressive cancer of lymphoblastic that can be Pre-B or Pre-T

A

ALL

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10
Q

MC form of ALL

A

Pre-B cell

Marrow/blood

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11
Q

Cancer of mature B cells with immunosuppression

A

Chronic lymphocytic leukemia (CLL

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12
Q

MC leukemia of adulthood

A

CLL

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13
Q

CLL MC diagnosed at

A

Age 60

Males 2X

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14
Q

CLL in ___ and survival is ___

A

Incurable

4-6 years

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15
Q

Pancytopenia (cells displacing marrow) and hypogammaglobulinemia observed in

A

CLL

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16
Q

Follicular lymphoma

A

Cancer of B cells in follicular center with nodular growths

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17
Q

25% of adult NHLs are

A

Follicular lymphomas

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18
Q

Centrocytes are ___ and are observed in ___

A

Lymphocytes with cleaved nuclei

Follicular Lymphoma

19
Q

Follicular lymphoma affects

A

Males and females equally

> age 50

20
Q

Follicular lymphoma is ___ and average prognosis is

A

Incurable

7-9 years

21
Q

40% of follicular lymphoma progress into

A

Diffuse B cell lymphoma (aggressive)

22
Q

85% of follicular lymphoma have ___, which causes what mutation

A

T(14;18)
BCL2 gene

Decrease B cell apoptosis

23
Q

Cancer of mature B cells constituting 5% of NHLs

A

Mantle cell lymphoma

24
Q

Mantle cell lymphoma MC diagnosed

A

Males

>50 years

25
Q

Mantle cell lymphoma is ___ and prognosis is

A

Incurable

4-6 years

26
Q

Mantle cell lymphoma involves what mutation

A

T(11;14)

Dysfunctional cyclins

27
Q

Mantle cell lymphoma is extranodal and common places include

A

Marrow
Spleen
Liver
GI

28
Q

MC lymphoma of adulthood

A

Diffuse large B cell lymphoma

35% NHL cases

29
Q

Risks for diffuse large B cell lymphoma

A

EBV

Immunosuppression

30
Q

Diffuse large B cell lymphoma MC age

A

60

Any age (15% pediatric lymphomas)

31
Q

Diffuse large B cell lymphoma may invade ___ and without treatment it is

A

Any organ

Rapidly fatal

32
Q

Cancer of B cells that classically affects African children

A

Burkitt lymphoma

33
Q

“Starry sky” histology involving B cell proliferation and apoptosis is observed in

A

Burkitt lymphoma

34
Q

Risks for burkitt lymphoma

A

EBV

Mutated MYC gene via t(8;14)

35
Q

Fastest growing human tumor

A

Burkitt lymphoma

36
Q

Burkitt lymphoma is MC extranodal and in Africa affects ___ and in US affects ___

A

Maxilla and mandible

Abdomen, GI, ovaries

37
Q

Favorable prognosis and most children are cured is a feature of

A

Burkitt lymphoma

38
Q

Plasma cell cancer MC diagnosed in the elderly, age ___, this gender, and what ethnicity

A

Multiple myeloma

Age 70

Males

African

39
Q

Multiple myeloma creates a “____” feature

A

Punched out (osteolytic lesions)

40
Q

Renal failure due to multiple myeloma with what proteins

A

Myeloma nephrosis

bence-jones proteins

41
Q

Diagnosis of multiple myeloma

A

Multifocal lytic lesions
Bence-jones proteinuria
M-spike on electrophoresis

42
Q

Neurological symptoms of multiple myeloma

A

HA
Dizziness
Tinnitus
Confusion

43
Q

Lethal complications from multiple myeloma

A

Bacterial infections

Kidney failure

44
Q

MC sites for lytic lesions

A 
Vertebral column 
Ribs
Skull
Pelvis 
Femur 
Clavicle 
Scapula

in order

Systems Path 2 (11 decks)

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