Exam 1: GI Cont. Flashcards
MC stomach infection
H. Pylori
Normal stomach defenses
Bicarbonate
Mucus
Mucus blood flow
Epithelial regeneration
NSAIDs inhibit what secretion
Bicarbonate
Inflammation of gastric mucosa
Gastritis
Significant bleeding caused by acute gastritis
Acute erosive hemorrhagic gastritis
3 typical NSAIDs
Aspirin
Ibuprofen
Naproxen
Symptoms of acute gastritis
Epigastric pain N + V Anorexia Hematemesis Melena
Acute peptic ulceration aka
Stress-related mucosal Disease
Small shallow ulcerations MC in stomach and duodenum, with symptoms of N + V, coffee-ground hematemesis
Stress-relelated mucosal disease
Caused of acute peptic ulceration
- Severe physiologic stress
- High NSAID dose
- Intracranial disease
___ is rare in chronic gastritis
Hematemesis
Potential causes of chronic gastritis
H pylori
Increase age
Chronic gastritis can lead to
Peptic ulcer disease
Gastric adenocarcinoma
70-90% of all cases of chronic gastritis positive for ____
H pylori infection
Risks for developing H pylori gastritis
Poor childhood sanitation/ hygiene
Autoimmune gastritis involves antibodies against
Parietal cells and Intrinsic factor
Autoimmune gastritis MC in what population
> 60 yo
Females
Autoimmune gastritis can cause what form of anemia
Pernicious
2 types of ca H pylori gastritis can cause
Gastric adenocarcinoma
MALT lymphoma
Autoimmune gastritis complicates ___
Erythropoiesis
Solitary “punched out” ulceration with pin point pain indicative of
PUD
PUD MC in what locations
Proximal duodenum
Gastric antrum
PUD contain what tissue
Granulation
Freq of PUD in population
10% males
4% females
Risks for PUD
H pylori
NSAIDs
Smoking
Alcohol
5-10% of everyone with H pylori will develop
PUD
Symptoms of PUD
N/V
Bloating
Cachexia
Epigastric pain (1-3 hrs postprandial)
Shared features of gastric and duodenal ulcers
Eating influences pain
Relieved by alkaline substances
Worse at night
Duodenal ulcers classic presentation
Postprandial relief (dairy)
Gastric ulcer classic presentation
Worse postprandial
Risk for gastric polyps
Chronic gastritis
___ makes up 75% of gastric polyps
Inflammatory and hyperplastic Polyps
___ makes up 15% of gastric polyps
Fundic gland polyp
___ makes up 10% of gastric polyps
Gastric adenomas
Gastric adenomas MC in __
Males (older age)
1/3 of gastric adenomas transition to
Adenocarcinomas
90% stomach cancer
Adenocarcinoma
10% stomach cancer
Lymphomas and carcinoid tumors
Stomach cancer MC ___ age ___, and ___ ethnicity
Males
55
Japanese