Female Reproductive Embryology Flashcards
At what week do gendered reproductive structures express themselves?
7
_____ ducts develop into male structures called ____.
mesonephric ducts called wolffian ducts
_____ ducts develop into female structures called ____.
paramesonephric ducts called mullerian ducts
Mullerian derivatives form what three structures?
uterus, fallopian tubes, and upper portion of vagina
What are the four key factors in determining male gonad fate?
testis determining factor, mullerian inhibiting factor, testosterone, dihydrotestosterone
What are the key factors in determining female gonad fate?
estrogen
Are M/F more likely to have congenital malformations? Why?
M –> more room for disruption since 4 different factors
What structures are formed by intermediate mesoderm in the developing abdomen?
kidney and ureters
At the point in time at which the mesonephric duct has induced kidney formation, do the gonads contain gonadal cells?
No
The _____ is a small segment of undifferentiated mesoderm that projects off the abdominal wall.
genital ridge
Where do primordial germ cells come from?
They migrate through the dorsal mesentery from yolk sac to genital ridge (in both sexes)
Which duct (male vs female) forms first?
mesonephric before paramesonephric
What affect does the arrival of primordial germ cells have on development?
stimulate undifferentiated gonad to form gender specific supporting cells (primitive sex cords)
What is the determining factor that establishes the m/f choice for a developing gonad?
Y –>Sry gene
The _____ encodes TDF
Sry gene on Y chromosome
The development of ovary fate is controlled by what gene pathway? What is the analog of this pathway in males?
Wnt4 is the analog of Sry in males
What are the supporting cells of male gametogenesis?
Sertoli cells
What do sertoli cells tell male germ cells to do once sertoli cells have been established?
signal them to not undergo gametogenesis in utero