Female Reproductive Embryology Flashcards

1
Q

At what week do gendered reproductive structures express themselves?

A

7

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2
Q

_____ ducts develop into male structures called ____.

A

mesonephric ducts called wolffian ducts

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3
Q

_____ ducts develop into female structures called ____.

A

paramesonephric ducts called mullerian ducts

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4
Q

Mullerian derivatives form what three structures?

A

uterus, fallopian tubes, and upper portion of vagina

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5
Q

What are the four key factors in determining male gonad fate?

A

testis determining factor, mullerian inhibiting factor, testosterone, dihydrotestosterone

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6
Q

What are the key factors in determining female gonad fate?

A

estrogen

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7
Q

Are M/F more likely to have congenital malformations? Why?

A

M –> more room for disruption since 4 different factors

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8
Q

What structures are formed by intermediate mesoderm in the developing abdomen?

A

kidney and ureters

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9
Q

At the point in time at which the mesonephric duct has induced kidney formation, do the gonads contain gonadal cells?

A

No

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10
Q

The _____ is a small segment of undifferentiated mesoderm that projects off the abdominal wall.

A

genital ridge

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11
Q

Where do primordial germ cells come from?

A

They migrate through the dorsal mesentery from yolk sac to genital ridge (in both sexes)

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12
Q

Which duct (male vs female) forms first?

A

mesonephric before paramesonephric

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13
Q

What affect does the arrival of primordial germ cells have on development?

A

stimulate undifferentiated gonad to form gender specific supporting cells (primitive sex cords)

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14
Q

What is the determining factor that establishes the m/f choice for a developing gonad?

A

Y –>Sry gene

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15
Q

The _____ encodes TDF

A

Sry gene on Y chromosome

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16
Q

The development of ovary fate is controlled by what gene pathway? What is the analog of this pathway in males?

A

Wnt4 is the analog of Sry in males

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17
Q

What are the supporting cells of male gametogenesis?

A

Sertoli cells

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18
Q

What do sertoli cells tell male germ cells to do once sertoli cells have been established?

A

signal them to not undergo gametogenesis in utero

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19
Q

What are granulosa cells?

A

granulosa/follicle cells are supporting cells in the developing ovary

20
Q

Do germ cells undergo gametogenesis in female gonads in utero?

A

Yes–> but arrest in M1 prophase

21
Q

Which endocrine cells are induced by sertoli and follicle cells respectively?

A

Leydig and theca cells

22
Q

The Leydig cells are the source of ____.

A

testosterone

23
Q

The theca cells are the source of ____.

A

estrogen (in addition to some from granulosa/follicle cells)

24
Q

The sertoli cells are the source of _____.

A

anti-Mullerian hormone/Mullerian inhibiting substance –> make mullerian ducts degenerate

25
Q

Testosterone is converted to ____

A

DHT –> masculinization

26
Q

What kind of epithelia are support cells of gonad? (sertoli, follicular)

A

coelomic epithelium

27
Q

What kind of epithelia are endocrine cells of gonad? (leydig, theca)

A

mesodermal stroma

28
Q

Where in the developing testis are testis cords located?

A

medulla

29
Q

Where in the developing ovary are ovary cords located?

A

cortex

30
Q

Site of gametogenesis in males

A

lumen of seminiferous tubules

31
Q

In which sex is the duct system completely closed

A

males

32
Q

Why is the female duct system not continuous?

A

the mesonephric duct degenerates, separating the ovary from the oviduct

33
Q

The paramesonephric ducts fuse under the influence of ____

A

estrogen

34
Q

The _____ form the fallopian tubes.

A

unfused ends of the paramesonephric ducts

35
Q

The lower part of the vagina is derived from ______

A

endoderm of urogenital sinus

36
Q

The ____ elongates to form the inferior vagina.

A

sinovaginal bulbs

37
Q

The paramesonephric ducts bring together a peritoneal fold that will form the ______ and create two peritoneal compartments.

A

broad ligament

38
Q

The ____ is created by resorption after paramesonephric duct fusion.

A

uterine cavity

39
Q

_____ is in the base of the broad ligament and courses through the cardinal ligament.

A

ureter

40
Q

The_____ is the deepest part of the female peritoneal cavity.

A

rectouterine pouch

41
Q

A ___ is a uterus with malformation resulting in two horns.

A

Bicorniate

42
Q

3 common components of external genitalia

A

glans area, urogenital folds, genital swelling

43
Q

In females the ____ forms the erectile tissue.

A

Glans area and genital swelling

44
Q

In females the ____ forms the glans of clitoris, shaft of clitoris, labium majora. .

A

urogenital folds and adjacent tissue

45
Q

In females the ____ forms the labium minora.

A

unfused urogenital folds