Female reproductive Flashcards
primordial follicle
- earliest stages of follicular devel
* single layer of squamous follicle cells with stretched out nucleus’s surround oocyte
balbiani body
localized accumulation of golgi bodies, ER, centrioles, mitochondria
primary follicle
- 1st growing stage of follicle
- CUBOID cells surrounding follicle
- zona pellucida - secreted pertinacious coat
follicle cells become?
granulosa cells after rapid replication as primary follicle
theca folliculi cells differentiate into two layers outside of granulosa cells
1) theca interna -highly vascularized cuboid STEROID producing secretory cells, fibroblasts and collagen
- -responds to LH by producing estrogen and androgen precursors
2) theca externa- outer layer of connective tissue; mainly smooth muscle cells and bundles of collagen fibers
boundary betwen theca interna and externa is?
indistinct; but the basal lamina and theca folliculi cells is distint
late primary follicle
- thick layer of granulosa cells, then basement membrane, then theca cells
- balbiani organelles disperse and multiply in cell
- have cortical granules
cortical granule
where sperm gains entry! closest to zone pellucida
oolema
oocyte plasma membrane
secondary follicles
*characterized by antrum
atrum
a bunch of hyaluronan (liquir folliculi) fluid filled spaces coalesce to form antrum
cumulus oophorus
thickened area of stratum granulosum in secondary follicles
corona radiate cells
cells incumulus oophorus that are in direct contact with oocyte and STAY IN CONTACT withreleased oocyte
cell-exner bodies
hyaluronan and proteoglycan aggregates between granulosa cells
mature or graafian follicles
spans entire thickness of ovarian cortex
*thecal layers more prominent
corpus luteum cells
1) granulosa cells (80%) central=estrogen, progesterone and inhibin (small dark)
2) theca lutein cells= periphery; androgens and progesterone (larger,paler)
corpus luteum becomes what if fertilization doesn’t occur?
corpus albicans
uterine tube parts
1) infundibulum
2) ampulla- fertilization
3) isthmus
4) uterine part
uterine tube layers
1) serosa or peritoneum- outer, mesothelium and CT
2) muscularis- inner thick and circular layer and outer thinner longitudinal layer
3) mucosa- thick folds projectin ginto lumen, most numerous in ampulla
lumen of uterine tubes is lined by?
1) ciliated columar cells- numerous in infundibulum and ampulla
2) nonciliated columnar cells- secretory and produce fluid providing nutreients to ovum
* depending on hormonal respinse the SAME cell can become ciliated or not
3 layers of uterus
1) endometrium- mucosallayer
2) myometrium- thick, continuous with muscle of uterine tube, smooth mucles extends into ligaments to connect uterus
3) perimetrium- out serous layer, loose CT, elastic tissue
proliferation phase
estrogen; follicular maturation, 10 days
secretory phase
progesterone secretion; corpus luteum activity (14 days), ENLARGED glands and lengthened arteries, glycogen rich
menstrual phase
hormone production by ovary declines with degradation of corpus luteum, 3-5 days, desquamation/sloughing, blood flor ceases to basal layer (but not functional)
mentrual cycle is ultimatly controlled by?
gonadotropins secreted by the par distalis of pituitary
lining of lactiferous duct, lactiferous sinus, and rest of ducts
duct= stratified squamous
sinus= two cuboidal cells
rest of ducts= single layer of cuboidal