Female Repro Flashcards
What forms the male and female tubular reproductive organs?
Wolffian tubules/ducts and Mullerian ducts
What part of the primordial germ cells migrate in to form the ovary?
Cortex
What part of the primordial germ cells migrate in to form the testis?
Medulla
What does the wolffian tubule and ducts form in the male and
Mullerian ducts in the female?
Male: Epididymus,
ductus deferens,
seminal vesicles,
ampulla
Female: Oviducts, uterus, cervix, anterior vagina
What does the urogenital sinus form in the male and female
Prostate
bulbourethral glands
Caudal Vagina
What does the gential tuburcle form in the male and female
Penis
Clitoris
What does the genital folds form in the male and female
prepuce
Vulva
What do the genital swellings form?
Scrotum
Vulva
Do males or female differentiate early on?
Males are earlier
What protein and factor induces undifferentiated gonad to develop into testes?
SRY protein
TDF
Which cell has Mullerian inhibitory substance and transcription factor important in diff of these cells
Sertoli Cells
What cells produce testosterone?
Interstital cells
specifically leydig cells
What does testosterone promotes and what else does it do?
Development of wolffian ducts
also converts DHT by the enzyme 5alpha reductase which induces development of penis,scrotum and prostate
What isn’t produced in females for sexual differentiation?
What is produced to help repress testicular development
SRY protein isn’t produced
DAX-1
What is a true hermaphrodite?
Someone who has both tissues in the gonadal tissue
what is a pseudohermaphrodite?
They will have male gonadal tissue or female gonadal tissue respectively
How does a freemartin occur?
Female calves are born co-twin with a male calf. There is a mixing of blood via large bore anastomoses with placentas so both calves will be chimeras bc the stem cells are mixed.
Why does a free martin occur?
MIS is produced in varying amounts in the female calf so the oviducts/uterus/cervix/anterio vagina do not develop properly
Is there communication of the cranial and caudal portions of the vagina in freemartins?
No!!!
also the external genitalia is normal to hypoplastic
What breed of dog does XX Sex reversal occur in?
Cocker Spaniels
What happens in XX sex reversal
Gonadal sex does not follow chromosal sex. XX true hermaphrodites and XX males.
XX true hermaphrodites are?
partially masculinized females with ovatestes
What are male pseudohermaphrodites?
They have 10% testicular tissue. Their external genitalia is malformed and are cyptorchid aspermatogenic testis
Why do these animals have abnormal development?
it is associated with an insertion on chromosome 9 and downregulation of RSPO1 in dogs.
Decreased or loss of this function can cause female to male sex reversal