Fatty liver disease

Question 1

When does a person have NAFLD?

Answer 1

When hepatic liver fat contributes to 5% or more of the liver weight

Question 2

Steatosis/fatty liver is linked to which other diagnosis?

Answer 2

• Insulin resistance
• Hyperglycemia
• Hypertension

Question 3

What is the main lipid in the liver?

Answer 3

Glycerolipid TAG

Question 4

How can we measure liver fat content?

Answer 4

• Liver biopsy
• Scanning with MR/MR
• Biomarkers

Question 5

How prevalent is NAFLD in the world?
(Non-alcoholic fatty liver disease)

Answer 5

25-30%

Question 6

Hepatic steatosis is inflammation that can be reversed with diet changes, but can cause fibrosis which is?

Answer 6

No longer live liver cells, but connective tissue. Gets harder and looses function

Question 7

What factors have negative effects on the liver?

Answer 7

Alcohol, tobacco, high fat diet, lack of sleep, abdominal fat and high blood pressure

Question 8

What two specific nutrients increase the prevalence of NAFLD?

Answer 8

Fructose (triggers lipogenese and triglyceride accumulation).
Saturated fatty acids.

Question 9

How much of total NAFLD cases occur in lean people?

Answer 9

10-20 %

Question 10

What are functions of the liver?

Answer 10

• Detoxification
• Metabolism
• Bile Production
• Storage: Stores vitamins and minerals.
• Protein Synthesis
• Manages cholesterol levels

Question 11

Where in the body does most of the hepatic lipids come from?

Answer 11

Adipose tissue (60%)