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Farma > farmacos antiepilépticos > Flashcards

farmacos antiepilépticos Flashcards

1
Q

Mecanismos de los antiepilépticos (3)

A

Inducir estado inactivo de canales de Na (no se despolariza)
Intensificar inhibición por GABA
Inhibir secreción de glutamato

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2
Q

epilepsia Tonico-clonicas generalizadas medicamentos (4)

A

Valproato
Lamotrigina
Fenitoína
Carbamazepina

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3
Q

epilepsia parciales medicamentos(2)

A

1° carbamazepina
2° fenitoina (difenilhidantoina)

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4
Q

epilepsia mioclonicas medicamentos (3)

A

1° valproato
2° Levetiracetam
3° topiramato o zonisamida

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5
Q

epilepsia ausencias medicamentos (2)

A

1° etosuximida
2° valproato

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6
Q

epilepsia estatus epileptico medicamentos (2)

A

1° diazepam
2° anestesia

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7
Q

Los tratamientos son curativo (V/F)

A

F

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8
Q

Fenitoina mecanismo de accion

A

modula los canales de Na y prolonga el estado inactivo de estos

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9
Q

fenitoina indicado en

A

convulsiones tonico-clonicas, generalizadas y parciales

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10
Q

Fenitoina sirve para las crisis de ausencia (V/F)

A

F, las favorece y las hace mas graves

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11
Q

Fenitoína farmacocinética (2)

A

Sustrato de CYP2C9
aumenta el metabolismo de anticonceptivos

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12
Q

Carbamazepina mecanismo de accion (2)

A

Modulador de canales de Na y Ca
Inhibidor de la transmision de glutamato

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13
Q

carbamazepina indicado en (2)

A

Convulsiones tonico-clonicas, generalizadas y parciales
Neuralgia del trigemino

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14
Q

Carbamazepina farmacocinetica(2)

A

Sustrato CYP3A4
Induce su propio metabolismo

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15
Q

Lamotrigina mecanismo de accion (3)

A

Modulador de canales de Na, Ca
Inhibidor de liberacion de glutamato
Potenciador GABA

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16
Q

Lamotrigina indicado en

A

Convulsiones tonico-clonicas, generalizadas y parciales

17
Q

Topiramato mecanismo de accion (4)

A

Bloquea canales de NA, Ca
Aumenta GABA

18
Q

Topiramato indicado en: (2)

A

Coadyudante de tx crisis parciales o monoterapia
migrañas

19
Q

Topiramato donde se absorbe y se elimina

A

Intestino y se elimina renal

20
Q

Valproato mecanismo de accion (3)

A

Modulador de canales de Ca
Aumento del tono GABAnergico
Inhibición glutamatergica

21
Q

Valproato indicado en: (3)

A

Convulsiones tonico-clonicas generalizadas
mioclónicas
Ausencias

22
Q

Valproato farmacocinéticas

A

Metabolismo en el higado
Inhibidor de CYP2C9 (sus sutratos son DFH y fenobarbital)
inhibidor de UGT (sus sustratos son lamotrigina y lorazepam)

23
Q

Etosuximida mecanismo de accion

A

Modulador de canales de Ca

24
Q

etosuximida indicado en

A

crisis de ausencia

25
Q

Espray nasal diazepam mecanismo de accion

A

agonista del receptor GABAa

26
Q

Espray nasal diazepam se indican en

A

episodios intermitentes estereotípicos de actividad convulsiva frecuente

Farma (21 decks)

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