F - 19 - Hydroxycobalamin Flashcards
1
Q
Class of hydroxycobalamin
A
Cyanide antidote/Vit. B12
2
Q
MOA of hydroxycobalamin in cyanide overdose.
A
Converts cyanide (C=N) to cyanocobalamin, which is excreted renally.
3
Q
T/F: Hydroxycobalamin is recommended in pediatric patients.
A
False
4
Q
If hydroxycobalamin is given to pediatric patients, what is the dose?
A
70 mg/kg.
5
Q
Adult dose of hydroxycobalamin in cyanide poisoning.
A
5 g/IV
6
Q
How is hydroxycobalamin prepared?
A
Place 5 mg hydroxycobalamin into a 200 mL NS bag to produce [25mg/mL]
7
Q
Contraindications to hydroxycobalamin.
A
Hypersensitivity to hydroxycobalamin, cyanocobalamin, or cobalt.
8
Q
Common side effects of hydroxycobalamin.
A
- Erythema
- Rash
- Nausea/vomiting
- HA
- HyperTN (SBP over 180 mmHg)
9
Q
Serious side effects of hydroxycobalamin.
A
- Ventricular ectopy
- Cardiac repolarization abnormalities
- Anaphylaxis
