2020 Protocol Test Review - CV Pharmacology

Question 1

Describe the MOA of Aspirin

Answer 1

Inhibition of Thromboxane A2 (and subsequent decreased platelet aggregation) through upstream cyclooxygenase (COX-2 PATHWAY).

Question 2

Cautions in ASA admininstration

Answer 2

• asthma
• chronic liver disease

Should STILL be administered if STEMI is present.

Question 3

Absolute contraindications for ASA

Answer 3

• Hypersensitivity to ASA/NSAIDS/Salicilates

- pregnancy

Question 4

What are the WSCEMSS indications for NTG?

Answer 4

• decompensated HF with pulmonary edema

- Cardiac chest pain in ACS

Question 5

What medication may decrease the vasodilatory effect of NTG and why?

Answer 5

Ergot (genus Claviceps - 1* a rye fungus);

1st type of Ergot poisoning - “St. Anthony’s Fire” - the serotonergic effect of ergot poisoning on monks in 1095 A.D.; dizziness, hallucinations, paralysis, etc.

2nd type: distal vasoconstriction 2/2 to ergot alkyoids

Question 6

Most ED drugs, when used within ____ hours, preclude the use of NTG. What is the exception?

Answer 6

48 hours; Viagra/Revation (sildenafil)