Extracellular matrix

Question 1

What is the glycocalyx

Answer 1

Question 2

What is the basement membrane (basal lamina)

Answer 2

Question 3

What are the three major molecules of the extracellular matrix

Answer 3

Question 4

describe adhesive proteins

Answer 4

Question 5

What are structural proteins

Answer 5

Question 6

Describe collagen

Answer 6

Basement membrane:
-Type 4 collagen
-non-helical segments + terminal globular domains (contains type 1)
-Creates lattice-like structure

-Insoluble framework determines mechanical properties of matrix
-Correlates tissue properties with 3D organization of collagen (tendons, cornea)

Question 7

What causes scurvy

Answer 7

Question 8

What are proteoglycans

Answer 8

Question 9

Describe proteoglycan structure

Answer 9

Question 10

What is fibronectin

Answer 10

Question 11

What is the role of fibronectin in development

Answer 11

Question 12

What is laminin

Answer 12

Question 13

What are the dynamic properties of ECM

Answer 13

Question 14

Simply summarize ECM

Answer 14

-Collagen fibrils form the basic insoluble framework of the ECM
-Laminins form a parallel network
-Proteoglycans are the fillers of the ECM
-Fibronectins and laminins strengthen the ECM