Cell cycle Flashcards
What is the cell cycle
What are the phases of the cell cycle
Briefly describe interphase
What are the mitotic stages
Explain the cell cycle control system check points
What are the key components of the cell cycle control system
What are cyclin-dependent protein kinases
What is maturation promoting factor (MAP)
Describe activation of Cdks
Describe Cdk phosphorylation/dephosphorylation
What are the Cdk inhibitor proteins
Describe how egulated proteolysis inluences Cdk activity
What are the cyclin classes and their functions
Explain the formation of mitotic chromosomes in prophase
Duplicated chromosomes prepared for segregation
Mitotic machinery assembled
Chromosome compaction/condensation occurs in early prophase
▫ Condensin - protein responsible for compaction
▫ Activated by phosphorylation of its subunits by cyclin-Cdk complex
▫ Pulls DNA loops positive DNA coiling condenses DNA
Describe centromeres and kinetochores in prophase
Explain the formation of the mitotic spindle in prophase
Explain prometaphase
Explain metaphase
What is the role of proteolysis in anaphase
The importance of protein degradation in regulating the events of
mitosis and the reentry of cells into G1 is best revealed with the use
of inhibitors.
No destruction of cyclin B (M cyclin) (by inhibiting the proteasome)
cells remain in a late stage of mitosis.
Describe the events of anaphase
What is the spindle assembly checkpoint (SAC) in anaphase
Describe telophase
what is the contractile ring theory in cytokinesis
Describe meiosis
