Cellular interactions Flashcards

1
Q

Briefly describe interactions of cells with ECM

A
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2
Q

Describe the structure of integrins

A
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3
Q

Explain the function of integrins

A

Outside-in signals influence cell:
-Differentiation
-Motility
-Growth
-Survival

Normal vs malignant cells:
-Normal: survive cultured on solid substratum (integrin binding) -> die in suspension
-Malignant can grow in suspension -> integrin independent

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4
Q

Explain outside-in signalling in Talin and Cytoplasmic tyrosine

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5
Q

What is the integrin binding sequence?

A

RGD amino acid sequence (arginine-glycine-aspartic acid)
-Fibronectin
-Laminin
-Other proteoglycans

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6
Q

What are cell-cell junctions

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7
Q

What are the key functions of the basement membrane

A
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8
Q

What are hemidesmosomes

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9
Q

What are tight junctions?

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10
Q

What are cadherins

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11
Q

Explain cadherins role in adherens junctions

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12
Q

Explain cadherins role in desmosomes

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13
Q

What are gap junctions

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14
Q

Summarize the structure and functions of cellular interactions

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