Cellular interactions Flashcards
Briefly describe interactions of cells with ECM
Describe the structure of integrins
Explain the function of integrins
Outside-in signals influence cell:
-Differentiation
-Motility
-Growth
-Survival
Normal vs malignant cells:
-Normal: survive cultured on solid substratum (integrin binding) -> die in suspension
-Malignant can grow in suspension -> integrin independent
Explain outside-in signalling in Talin and Cytoplasmic tyrosine
What is the integrin binding sequence?
RGD amino acid sequence (arginine-glycine-aspartic acid)
-Fibronectin
-Laminin
-Other proteoglycans
What are cell-cell junctions
What are the key functions of the basement membrane
What are hemidesmosomes
What are tight junctions?
What are cadherins
Explain cadherins role in adherens junctions
Explain cadherins role in desmosomes
What are gap junctions
Summarize the structure and functions of cellular interactions