Exam - Iodine Flashcards

1
Q

supplement label of iodine

A

thyroid gland support

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2
Q

is iodine prevalent in most foods

A

no, iodine content is low

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3
Q

what is iodine

A

inorganic mineral that is highly water soluble

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4
Q

where is iodine found in higher concentrations

A

in coastal populations opposed to mountainous regions

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5
Q

what kind of food has high iodine concentration

A

seafood - especially sea greens

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6
Q

where does most iodine consumed come from in North America

A

salt fortified with potassium iodine

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7
Q

how many mg of iodine does iodized salt contain per g of salt

A

0.03

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8
Q

as of 2007, what percentage of the world population live in areas of iodine deficiency

A

29%

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9
Q

how can dietary iodine be found

A

bound to amino acids or free

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10
Q

what occurs to iodine in our GI tract

A

iodine is rapidly converted to iodide (ionic form) and absorbed

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11
Q

where does iodine get absorbed

A

mostly in stomach, a bit in small intestine

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12
Q

what does free iodide do in blood

A

circulates and can enter all tissues

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13
Q

where does most of free iodide accumulate

A

thyroid gland

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14
Q

what percentage of the iodine in our body is located in the thyroid gland

A

70-80%

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15
Q

what is the uptake of iodide mediated by

A

active transport system: Na+/I- symporter (NIS)

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16
Q

do all tissues depend on iodine

A

no, all tissues depend on thyroid hormones T3 and T4 rather than iodine itself

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17
Q

what happens to T3 and T4 after they are made

A

they are released into blood and transported by carrier proteins

18
Q

is there more T4 or T3 in blood

A

50x more T4 than T3 in blood - but T3 is 100x more potent

19
Q

what does T3 interact with

A

thyroid hormone receptor

20
Q

what is T3 and T4 production regulated by

A

thyroid stimulating hormone

21
Q

what occurs when T3 levels are low

A

the hypothalamus signals to the pituitary to release TSH

22
Q

what is thyroglobulin (THG)

A

tyrosine-rich protein

23
Q

what do thyroid hormones influence

A

how body stores and uses energy

24
Q

things that thyroid hormones control

A
  • breathing
  • heart function
  • nervous system function
  • body temp
  • cholesterol level
  • energy balance
  • brain development
  • skin moisture
  • menstruation
25
Q

what does it mean that T3 and T4 are lipophilic

A

they can easily cross plasma membranes

26
Q

what does T3 do in tissues

A

binds to THR which then binds to response elements in promoter regions of DNA to activate gene expression

27
Q

examples of genes activated by T3

A

ATPases
Growth hormone

28
Q

what does the pituitary gland release when T3 levels are low

A

TSH

29
Q

what is occurring when iodine is deficient

A

the thyroid is still being stimulated by TSH to make hormones but it can’t

30
Q

what is the result of the thyroid being unable to make hormones

A

hyperplasia
hypertrophy

31
Q

hyperplasia

A

increase in cell number

32
Q

hypertrophy

A

increase in cell size

33
Q

result of iodine deficiency

A

goiter in adults
cretinism

34
Q

what is a goiter

A

thyroid enlargement

35
Q

what is cretinism

A

when iodine levels are low in mother, fetus does not develop properly

36
Q

what does goiter lead to

A

thyroid cancer if left untreated

37
Q

what can mild goiters be treated with

A

iodine supplements

38
Q

what does cretinism lead to

A

growth and developmental abnormalities - irreversible

39
Q

how many people are affected by iodine deficiency disease

A

over 740 million (13% of world population)

40
Q

how many people have some degree of intellectual disability caused by IDD

A

50 million