Exam - Vitamin B6 Flashcards
supplement label
converts carbs, proteins, fats to energy
what does vitamin B6 exist as
6 vitamers that are interchangeable and comparably active
what are the 6 vitamers
phosphorylated and unphosphorylated pyridoxine, pyridoxal, pyridoxamine
which vitamers are the plant provitamins
pyridoxine
where are all isomers found
foodd
what occurs to B6 prior to absorption
dephosphorylated
how is B6 absorbed
passive diffusion in jejunum
what is the main form of B6 found in blood, bound to albumin
PLP
where are high levels of B6 found
muscle
where do B6 conversions primarily occur
liver
what is PLP
cofactor for many enzymes including amiotransferases
what is B6 involved in the first step of
pophryin (heme) synthesis
what does B6 take part in
synthesis of neuroactive amines
what does vitamin B6 deficiency cause
microcytic anemia
what does PLP =
co-enzyme
what are stem cells in bone marrow differentiated in the presence of
erythropoietin (EPO)
what does differentiation normally cause red blood cells to do
shrink, nucleus is removed, able to carry O2
what is the differentiation process for red blood cells very sensitive to
micronutrient deficiencies - leads to anemia
3 types of anemia
- megaloblastic anaemia
- hemolytic anameia
- microcytic anaemia
what is the result of megaloblastic anemia
bigger cells get produced
