Exam 3: Physiology of Liver & Pancreas Flashcards
How does blood flow from the portal vein through the liver?
Portal vein–>Sinusoids–>Central vein–>Hepatic veins
How does blood flow from the hepatic artery through the liver?
Hepatic artery–>Sinusoids–>Central vein–>Hepatic veins
What does the Space of Disse flow into?
Lymph ducts
What effect does cirrhosis have on blood flow of the liver?
Increases resistance to blood flow
What is the normal volume of the liver?
450ml (10% of blood volume in body)
T/F: Liver cannot store blood or supply blood in times of excess or need.
False, it can do both
Hepatic sinusoids are highly permeable to _____.
Proteins
Higher than normal pressure in hepatic veins and large fluid build up in abdominal cavity is called…?
Ascites
Which vitamins are stored in the liver?
A, D, B12
What is the major pigment in bile?
Bilirubin
Where is urobilinogen created and where can it go?
Intestines.Out in feces as stercobilin or back to liver & circulation again
What disease is caused by bilirubin in the extracellular matrix?
Jaundice
Increased hemolysis & obstruction of bile ducts or damage to liver are causes of what?
Jaundice
What do Alpha cells in the pancreas secrete?
Glucagon
What do Beta cells in the pancreas secrete?
Insulin & Amylin
What do Delta cells int he pancreas secrete?
Somatostatin
How does proinsulin become active insulin?
Removal of the C-chain
In glucose uptake, insulin _____ liver phosphorylase, _____ glucokinase, & _____ enzymes for glycogenesis
Inactivates.Activates.Increases
T/F: Insulin inhibits gluconeogenesis.
True
TQ: What is the most important role of insulin?
Determine whether cells use glucose or fats as energy source
Insulin _____ conversion of excess glucose into fatty acids & _____ utilization of fat.
Promotes.Decreases
T/F: Insulin only initiates the conversion of glucose to fat.
False, also helps fat cells take up the fat
In reference to fat storage, lack of insulin causes large amounts of _____ & _____ _____ to be released in the blood.
GlycerolFatty acids
Glucagon is trying to _____ glucose levels in the blood.
Increase
