Exam 3 Part 3 Flashcards
Proteoglycans
Component of ECM, repeating structure of proteins and sugars
glycosaminoglycans
GAG - proteins linked to long chains of negatively-charged polysaccharide polymers
glycosaminoglycans
GAG - proteins linked to long chains of negatively-charged polysaccharide polymers
functional properties of proteoglycans
negative charge attract Na+ which attracts water, results in a gel-like consistency
Provides protection against compression, shock absorption, lubrication, and space filing
occupy large volume relative to mass
combination with tensile strength of collage nmakes a very though tissue: can support hundreds of kg/cm2
polarization of epithelial cells at the surface
= function
junctions help with sidedness
apical and basal sides
tight junction
seals neighboring cells together in an epithelial sheet to prevent leakage of extracellular molecules between them;helps polarize cells
adherens junction
joins an actin bundle in one cell to a similar bundle in a neighboring cell
desmosome
joins the intermediate filaments in one cell to those in a neighbor
gap junciton
forms channels that allow small, intracellular, water-soluble molecules, including inorganic ions and metabolites, to pass from cell to cell
hemidesmosome
anchors intermediate filaments in a cell to the basal lamina
tight junction proteins
occludin and claudin
seal to itself not each other
cadherin
in adherens junction
transmembrane protein that bind to each other outside cells and to a linker protein inside cells
adherens junctions protein
cadherin
occludin and claudin
tight junction proteins
adhesion belt
vital for developmental movements
form from adherens junctions