Exam 2 Cont. Flashcards
Benign epithelial growths on skin or mucus membranes
Warts
MC warts
Fingers and toes (seed warts)
Plantar warts are found
On soles of the feet
Flat warts
Warts located on trunk, face, elbow, and knees
Human Paillomavirus (HPV)
Causes warts
Warts are transmittted via
Direct contact and fomites.
Autoinoculation with warts
warts can spread from one location to another on the person
Exanthems
Rash
5 classical childhood exanthems
- Rubeola (measles)
- Scarlet fever
- Rubella (German measles)
- Erythema infectiosum
- Roseola
Measles AKA
Rubeola
Koplik’s spots
White spots that appear in the mouth of those infected with measles
Complications of measles
Pneumonia, encephalitis, subacute sclerosis’s panencephalitis (SSPE)
Measles virus
Pathogen causing measles
Measles is ______ contagious
Highly
Infectious for 4 days pre-rash and 4 days after rash appears
Spread of measles
Respiratory droplets
-humans are the only host
Vaccine for measles
MMR
Rubella AKA
German Measles or 3-day measles
Characteristics of German measles
Rash of flat, pink to red spots
Rubella infection in children is
Not serious
Adult Rubella infection
More dangerous than children. Develop arthritis or encephalitis
Extra dangerous in pregnant women
Congenital Rubella Syndrome
Infection of pregnant women can cause birth defects or death of the fetus by crossing the placenta.
Mom will be fine, baby is not
Rubella virus
Rubella pathogen
Spread of German Measles
Respiratory secretions
MMR vaccine
Mumps, Measles, Rubella
Rubella vaccine
Aimed at preventing rubella infections in women
Congenital Rubella syndrome can cause
Cloudy corneas or white appearance to pupil, deafness, developmental delay, low birth weight, intellectual disability, seizures, and microcephaly in children
Spontaneous abortion occurs in ____% of cases with CRS
20%
Erythema infectiosum AKA
Fifth disease
Common symptom of fifth disease
Slapped cheek syndrome
Erythema infectil sum is a ______ disease that manifests as a rash
Respiratory
sunlight aggravates this condition
Fifth disease
Parvovirus B19
Pathogen causing erythema infectiosum/ fifth disease
Spread of erythema infectiosum
Respiratory droplets
Once rash is present the person is no longer infectious
Symptoms of roseola
Abrupt fever, sore throat, enlarged lymph nodes, pink rash on face, neck, trunk, and thighs
Roseola can cause _________ like symptoms
Mononucleosis
Diseases that may be linked to roseola
AIDS and multiple sclerosis
Human Herpesvirus-6
Pathogen causing roseola
Spread of roseola
Person to person by transfer of oral secretions
Mycoses are caused by
Fungi
2 Characteristics of Mycoses
Opportunistic
Not contagious
Piedra
Irregular nodes on hair shaft. White and black forms
Black piedra forms
Hard, black nodules
White piedra forms
Soft, gray to white nodules
Piedraia hortae
Black piedra
Tricosporon beigelii
White piedra
Spread of piedra
Person to person contact or environmental exposure (shared hair brushes and combs)
Treatment of piedra
Shaving infected hair
Pityriasis versicolor AKA
Tinea versicolor
Pityriasis versicolor
Hypo or hyperpigmented patches of skin on trunk, shoulders, and arms
Malassezia furfur causes
Pityriasis versicolor
Spread of pityriasis versicolor
Person to person contact or environmental exposure
Tanning beds
Diagnosed by a green color under UV light
Pityriasis versicolor
Cutaneous mycoses
Cutaneous infections caused by dermatophytes
Cutaneous mycoses AKA
Ringworm… but there are NO worms involved. It’s a fungus
Transmission of cutaneous mycoses
Between people via fomites
Dermatophytoses are ______ and aggravated by ________
Often itchy; aggravated by heat and moisture
Diagnosing dermatophytoses
KOH preparation of skin or nail sample
Tinea pedis
Athlete’s foot
Tinea curis
Jock itch
Tinea unguium
Finger and toe nails
Tinea corporals
Body
Tinea capitis
Head
Tinea unguium AKA
Onychomycosis
Genus names associated with dermatophytoses
Trichophyton
Epidermophyton
Microsporum
Wound mycoses
Sporotrichosis
Sporotrichosis AKA
Rose-gardener’s disease
Cutaneous sporotrichosis
Nodular lesions around the infection site
Lymphocutaneous sporotrichosis
Secondary lesions occurring on the skin along the course of lymphatic vessels
Sporothrix schenckii causes
Sporotrichosis
Sporotrichosis is introduced by
Thorn pricks or wood splinters (soil is the reservoir)
People who _________ are at the highest risk for sporotrichosis infections
Work with plant material
Leishmaniasis can appear in 3 places
Cutaneous
Mucocutaneous
Visceral
Cutaneous leishmaniasis
Produces large painless skin lesions
Mucocutaneous Leishmaniasis
Skin lesions enlarge to encompass mucous membranes
Visceral leishmaniasis
Parasite is spread by macrophages throughout the body
Leishmania is the causative agent of
Leishmaniasis
Leishmaniasis endemic
Parts of the tropics and subtropics
Reservoir and vector for leishmaniasis
Dogs are the reservoir, transmitted to humans by sand flies (vector)
Leishmaniasis AKA
Kala azar
Scabies signs and symptoms
Intense itching and a rash of small, red, LINEAR bumps at infection site
May see burrows or tunnels
Pathogen of scabies
The mite or Sarcoptes scabiei
Transmission of scabies
Prolonged bodily contact, epidemics occur in crowded conditions
Treatment of scabies
Mite-killing lotions and cleaning of contaminated items. Antihistamines are used to help with itching
Often treat family members and sexual contacts
CNS is an _____ environment
Axenic
Pathogens may enter the CNS by:
- Breaks in bones and meninges
- Medical procedures
- Travel from PNS
- Infect and kill cells of meninges, causing meningitis
Bacteria can cause nervous system diseases in 2 ways
- Infect cells of the nervous system
2. Bacteria growing somewhere else releases toxins that affect neurons
Infected cells of the nervous system cause
Meningitis and leprosy
Bacteria growing elsewhere that released toxins to the neurons
Botulism and tetanus
Signs and symptoms of bacterial meningitis
Severe headache and neck stiffness along with fever, confusion, altered consciousness, vomiting, photophobia or phonophobia
Severe meningeal inflammation
Encephalitis
Encephalitis with bacterial meningitis
Can cause behavioral changes, coma, and death
Bacterial meningitis develops
RAPIDLY
5 bacteria’s that cause 90% of bacterial meningitis cases
- Neisseria meningitidis
- Streptococcus pneumoniae
- Haemophilus influenzae b
- Listeria monocytogenes
- Streptococcus agalactiae
Streptococcus agalactiae
Acquired during birth and can cause meningitis is babies less than 3 months old
Streptococcus agalactiae is present in ______% of women
50% regularly; causes no problems in the adult
Haemophilus influenzae b
Transmitted via respiratory droplets
Meningitis in children <5 (MC under 18 months)
Streptococcus pneeumoniae
Present in throat of 75% of humans
Transmitted via respiratory droplets or opportunistic
MC cause of meningitis in adults
Listeria monocytogenes
Transmitted via contaminated food
MC in elderly, babies, and pregnant women
Neisseria meingitidis AKA
Meningococcal meningitis
Neisseria meningitidis unique symptom
Purple spotted rash
Along with other meningitis symptoms
Transmission of neisseria meningitidis
Via respiratory droplets
Neisseria meningitidis MC in
College students in dorms (23X more likely)
Families, soldiers in barracks, prisoners
Diagnosis of meningitis
Symptoms and culturing bacteria from CSF (spinal tap)
Vaccines for bacterial meningitis
S. Pneumoniae (PCV)
H. Influenzae b (Hib)
N. Meingitidis (MCV)
Leprosy AKA
Hansen’s disease
Signs and symptoms of leprosy
Skin sores, nerve damage, and muscle weakness
A strong immune system will develop _____ leprosy
Tuberculoid
Tuberculoid leprosy
Nonprogressive
Regions of lost sensation of skin
Weaker immune system develops ________ leprosy
Lepromatous
Lepromatous leprosy
Multiplies in skin and nerve cells.
Progressive, gradual loss of facial features, digits, and other body structures
Development is very slow and may take years
Death from leprosy is
Rare
Mycobacterium leprae
Causes leprosy
Regions of body where mycobacterium leprae thrives
Cooler regions
Peripheral nerve endings and skin cells of fingers, toes, lips, and earlobes
Reservoir for mycobacterium leprae
Armadillos
Transmission of leprosy
Person to person contact or breaks in the skin
Mycobacterium is
Acid fast
Treatment of leprosy
Multiple antibiotics; lifelong treatment is sometimes needed
BCG vaccination provides some protection
Mycobacterium infections are
Very hard to treat; require multiple antibiotics
Botulism is an
Intoxication
Intoxication
Poisoning by ingested toxin
3 forms for botulism
Foodborne
Infant
Wound
Botulism is ______ potent
Extremely
Small taste of contaminated food can cause death
Type of paralysis caused by botulism
Flaccid paralysis
Pathogen of botulism
Clostridium botulinum
Clostridium botulinum produces
7 neurotoxins that bind irreversible to neuromuscular junctions
Foodborne botulism appears 1-2 days after
Consuming toxin in home-canned foods or preserved fish
Patients die from ______ with botulism
Asphyxiation
Recovering from botulism
Very slow as nerve cells grow new endings over the course of months or years
Cause of infant botulism
Ingestion of endospores that germinate and colonize the GI tract
Endospores are common in
Honey
Food that should not be given to children less than a year old
Honey and corn syrup
Signs and symptoms of infant botulism
Floppy baby syndrome
Crying, constipation, failure to thrive
Cause of wound botulism
Contamination of a wound by endospores
Difference between wound and foodborne botulism
Wound has no GI system involvement, no signs of botulism until flaccid paralysis shows up
Treatment of botulism
Repeated washing of the intestinal tract to remove clostridium
Administration of antitoxin
Antimicrobial drugs in infant botulism
Prevention of botulism
Proper food canning
Don’t give babies honey or corn syrup
Tetanus AKA
Lock jaw
Pathogen of tetanus
Clostridium tetani
Clostridium tetani neurotoxin
Tetanospasmin
Risus sardonicus
Smiling spasm
Signs and symptoms of tetanus
Tightening of neck and jaw muscles (lock jaw) and then smiling spasm (risus sardonicus)
Severe, unrelenting spasm (spastic paralysis)
Death caused by tetanus
Asphyxiation, cannot exhale
Spread of tetanus
Through a break in skin or mucous membrane
clostridium tetani is most commonly grown in
Soil
Grows in environments where rust does grow, not caused by rust
Neonatal tetanus mortality
> 90%
Neonatal tetanus infection via
Infected umbilical stump
Treatment of tetanus
Clean wound (remove endospores)
Antitoxin
Tetanus toxoid
Antibiotics
Highest mortality rate in tetanus occur in
Unvaccinated people and people over 60