Exam 2: Adrenergic Agonists

Question 1

indirect work on ___

Answer 1

the release of catecholamine

Question 2

direct acting

Answer 2

clonidine, dobu, dopa, epi, iso, NE, Neo, midodrine, precedex, ephedrine

Question 3

indirect acting

Answer 3

amphetamine, coke

Question 4

catecholamine structure

Answer 4

catechol on 3&4 and an amine group

Question 5

noncatecolamines lack a what and aren’t inactivated by what

Answer 5

catechol hydroxyl group and COMT

Question 6

Bc of the substitution at the alpha carbon,MAO is ____ in noncatecholamines

Answer 6

blocked

Question 7

___ is more or equally efficacious at alpha compared to ___, which is more efficacious than ___

Answer 7

epi, NE, iso

Question 8

___ is more efficacious than ___ which is greater than or equal efficacy of ____ @ beta

Answer 8

iso, epi, Ne

Question 9

B1 is equal affinity for ___ and ___, but at B2, ___ is more efficacious than ____

Answer 9

epi, NE x2

Question 10

A1 causes ___, B1/2 increases ____ and A2 decreases ____

Answer 10

vasoconstriction, cAMP x2

Question 11

NET is blocked by ____ and reversed by ____, creating more ___ at the site.

Answer 11

coke, amphetamines, NE

Question 12

CO = __ x __

Answer 12

SV, HR

Question 13

eye: __ agonist causes ___, and __ antagonist causes a decrease in aqueous humor. B agonist has no ___

Answer 13

alpha-> dilation, beta, effect

Question 14

B2 agonists cause broncho___ and GI relaxation occurs with ___ and ___

Answer 14

dilation, alpha and beta stimulation

Question 15

epi works on __ and __, NE works on ___ and ___, Iso only works on ___, Dopa works on ___ primarily, higher doses __and ___, Dobutamine works only on ___. clonidine works only on ___ (sympathoplegic effect)

Answer 15

alpha and beta, alpha and beta1, iso- beta, D1-5, a1 and b1, dobut -B1, alpha 2

Question 16

we don’t see any lung effects with NE bc it doesnt work on ___, whereas __ does

Answer 16

B2, epi

Question 17

low dose dopa works on __ receptor, middle dose works on ___ receptor, high dose dopa works on ___ receptor

Answer 17

dopamine, beta 1, alpha

Question 18

dobutamine is good for what issues?

Answer 18

cardiac shock and acute heart failure

Question 19

phenylephrine is a pure __ agonist, is used as a ___ and it can raise BP

Answer 19

alpha, decongestant

Question 20

midodrine is __ selective and works on _____

Answer 20

alpha 1, postural hypotension

Question 21

ephedrine releases stored ____ and mimics ___, also used as a ___

Answer 21

catecholamines, epi, decongestant

Question 22

amphetamines enter the ___ and increase ___ and suppress ___

Answer 22

CNS, attention, appetite

Question 23

coke enters the ___ and inhibits ____ reuptake

Answer 23

CNS, dopamine

Question 24

tyrosine is a ___, it creates tyramine that is metabolized by ___, shouldn’t eat fermented foods when taking an _____, because it increases tyramine levels

Answer 24

precursor, MAO, MAOI

Question 25

heart block treatments

Answer 25

atropine, epi, dopa, iso, and pacemakers

Question 26

B2 agonists for lungs include

Answer 26

albuterol, terbutaline

Question 27

clonidine treats ___ by decreasing BP via the ___

Answer 27

HTN, CNS

Question 28

dex is used for ___ by working on ___ in the CNS

Answer 28

sedation, alpha 2