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Pharm > Chemo Shit > Flashcards

Chemo Shit Flashcards

1
Q

Neoplasm means what

A

new growth

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2
Q

metastasis means what

A

spreads to distant site, malignant neoplasm

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3
Q

carcinoma cancer typer

A

epithelial origin

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4
Q

sarcoma cancer type

A

connective tissue or muscle

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5
Q

leukemia or lymphomas

A

immune cells

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6
Q

CNS cancer

A

glioma or retinoblastoma

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7
Q

treatemtn of cnacer

A

surgery,m radiaiton, chmeotherapy

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8
Q

primary chemo

A

limit spread

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9
Q

neoadjuvant

A

surgery amd more chemo, reduces tumor size

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10
Q

adjuvant chemo

A

after surgery, reduce incidence and resurgence of tumor

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11
Q

chemo admin

A

oral, IV, topical, intra cavity

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12
Q

cell cycle

A

G1 to s to G2 to mitosis to made cell

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13
Q

cancer cells ___normal mechanism of suppressing cell growth

A

lack

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14
Q

anti-cancer drugs ____ cells that are ___

A

target, dividing

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15
Q

cell cycle specific agents

A

act against specific proteins involved in cell progression

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16
Q

cell cycle nonspecific agents

A

effect not reliant on cell cycle progression

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17
Q

main goal

A

cure and remission

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18
Q

drugs are given as frequently as ___ in carefully timed cycles

A

tolerated

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19
Q

we want to avoid

A

resistance

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20
Q

____ drug therpay can negate the effects of resistances of the different drugs

A

combination

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21
Q

primary resistance

A

mutatiosn prevent drug from working

22
Q

acquired resistance

A

drug treatments selects for resistant strains

23
Q

alkylating agents

A

transfer alkyl groups to target DNA, makes it inactive

24
Q

alkylating agents either ___ DNA or interfere by ____

A

alkylate, cross-linking

25
Q

alkylating agent groups

A

nitrogen mustards, nitrosureas, alkyl sulfonate, platinum analogs

26
Q

cisplatin is what drug group

A

platinum analog

27
Q

alkylating agents form

A

highly reactive carbonium ions

28
Q

then, alkylating agents ____ alkyl groups to ____ sites on DNA base

A

transfer, nucleophilic

29
Q

after alkyl groups are transferred, it results in

A

decrease cell proliferation

30
Q

cyclophosphamide is good for what

A

neoplastic and nonneoplastic

31
Q

leukeran works on what

A

leukemia

32
Q

nitrosureas cross the ____ and is the DOC for ___ tumors

A

BBB, brain

33
Q

cisplatin is ____ to protein

A

highly bound

34
Q

cisplatin treats what cancers

A

testicular and ovarian

35
Q

cisplatin enters the cell and forms _____ reactive platinum complexes

A

highly

36
Q

after forming reactive platinum complexes, it cross links ____ and ____

A

interstrand and intra strand

37
Q

Overall cisplatin causes ___ damage

A

DNA

38
Q

cisplatin then ____ cell proliferation

A

inhibits

39
Q

methotrexate is a ___

A

antimetabolite

40
Q

methrotextae is what kind of antimetabolitw

A

folate antagonist

41
Q

methotrexate inhibits ____ reductase and interferes with ____ synthesis

A

dihydrofolate, DNA/RNA

42
Q

3 actions of methotrexate

A

cytotoxic, immunosuppressive, anti-inflammatory

43
Q

other antimetabolites consist of

A

6-MP, 5-FU

44
Q

plant based

A

vincristine and paclitaxel

45
Q

antibioitcs

A

dactinomycin, doxorubicin and bleomycin

46
Q

hormonal agents

A

corticosteroids, tamoxifen and fulvestrant

47
Q

miscellaneous chemo

A

imatinib, trastuzumab, and rituximab

48
Q

cyclophosphamide is what kind of drug

A

nitrogen mustards

49
Q

chlorambucil is a nitrogen mustards and is ___ toxic

A

least

50
Q

nitrosureas cross the ___

A

BBB

Pharm (23 decks)

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