Ex 2- Periodontium 3- PDL + Alveolar Bone Flashcards
_____ is the soft connective tissue btw cementum and the bony wall of the tooth socket continuous with gingival connective tissue cervical and apical foramen apically
PDL
The major components of the PDL are its large, highly organized bundles of _____ fibers that have their ends embedded in ________ and _____
collagen
cementum
bone
The PDL has the critical function of attaching _____ to _____
tooth to bone
The PDL is very ________ and gets slightly _______ with age
thin (.2-.4mm)
thinner
What are the cells of the periodontal ligament (PDL)?
fibroblasts cementoblasts osteoblasts + osteoclasts epithelial rests of Mallasez immune cells undifferentiated mesenchymal cells (stem cells)
_______ are the most numerous cells of the PDL
fibroblasts
Fibroblasts are large cells (size indicates activity) that secrete + degrade ______
collagen
PDL fibroblasts have a variety of cell-to-cell contacts including ______, _____ ____, and _____-______ junctions
desmosomes
gap junctions
cell-ECM
______ _____ synchronized collagen secretion
gap junctions
Fibroblasts exhibit junctions w/ ECM, one type is called a _____ because the extracellular matrix molecule fibronectin forms part of this junction
fibronexus
Fibroblasts are most prominent in the ______ part of the periodontal ligament. Cementoblasts at the _______/PDL border. Osteoblasts + osteoclasts near _____
central
cementum
bone
The cell-ECM junction is the functional link between ______ ______ and _____. Allowing the fibroblast to react to the forces (ie secreting and degrading ______)
occlusal forces
fibroblasts
collagen
The cell-ECM junction helps to maintain the orientation of _____ in PDL thus affecting orientation of _______ _____ _____
fibroblasts
collagen fiber bundles
Cell (fibroblast)-ECM juncion have links to ____ cytoskeleton that ultimately interact with ______ in the ECM through either single _______ molecule or complex of molecules
actin
collagen
transmembrane
Cementoblasts, osteoblasts, osteoclasts are all located where in the PDL?
closest to the tissue they form
Osteoclasts can be distinguished from adjacent cells by the presence of _______ _____
multiple nuclei
_______ are rare in the PDL
cementoclasts
Cementum is NOT undergoing _______ remodeling like bone or the PDL but cementum is resistant to _______
constant
resorption
Notable resorption of cementum occurs in SPECIAL SITUATIONS like shedding of the ______ _____ or ____
deciduous
trauma
______ ____ ___ ______ are remnants of HERS present in the PDL. They are epithelial cells that lie in clusters closer to the cementum than alveolar bone
Epithelial rests of Mallasez
Epithelial rests of Mallasez have _____ functions in mature teeth but when the PDL is inflamed, rest cells proliferate and form _____
unknown
cysts
________ ________ cells lie close to blood vessels, are though to be a ______ stem cell that give rise to new fibroblasts, cementoblasts + osteoblasts
undifferentiated mesenchymal (stem) pluripotent