Epidemiology & Pathogeneis Part 1 Flashcards
What does pathology mean?
Scientific study of disease
What does etiology mean?
Cause of a disease
What does pathogenies mean?
The way a disease develops, all structural and functional changes
What does infection mean?
Invasion or colonization of the body, by a pathogenic microbe
What does disease mean?
When an infection leads to a change in normal statues of health
Give me an example where is there an infection but no dieases?
HIV
What is another example is where people carry the infection but no disease?
Asymptomatic individuals
( covid, herpes )
What does host mean?
Any organism that harbors another organism
What does normal flora mean? What is their function ?
Permanent and usually not pathogenic microorganisms
( fight pathogenic micrograms )
What is resident flora?
Always present on or in the human body
What is transient flora?
Will come and go
( few hours to a few months )
What does birth mean?
Microorganism being to establish themselves
What are examples of normal flora?
Lactobacilli from mothers vagina
Do we have more cells or bacteria in our body? Typically?
Bacteria
What was the extensive and supported evidence about normal flora?
Keeping a healthy normal flora, directly decreases the chances of infection and disease
What is the human micro biome project that started in 2007?
A project to help identify all the microbes found in different parts of the body
What is a physical way that flora fights infection?
Skin barrier
What are the 3 ways flora fights off or works with infections?
Mutualism
Antagonism
Parasitism
What does mutualism?
Both organism benefit
What is an example of mutualism?
E. coli in intestine produces vitamin k and B
What is antagonism?
Competition between microorganism
( competitive exclusion )
( Normal flora vs pathogen )
What is an example of antagonism?
Bacteriocins
( proteins secreted by E. coli cause clostridium difficult to overgrow after antibiotic therapy )
What is parasitism?
One organism benefits and the other is harm
What is an example of parasitism? Any what?
Any successful pathogenic microorganisms
Does the host and normal flora exist together?
Yes
Does the normal flora live in symbiosis with the human body?
Yes
What does symbiosis mean?
Association between two or more species
What does commensalism mean?
One organism benefits and the other is not affected
What is an example of commensalism?
Staphylococcus epidermis, on our skin
( the normal flora usually benefits the host by preventing pathogens from over growing )
What is the main way that normal flora helps us fight pathogens ?
( best way to fight off infection )
Competitive exclusion, or metabolism
What is going on competitive exclusion? (3)
that the pathogen & flora are fighting of food, energy sources and space
How does competitive exclusion help our normal flora? (2)
By keeping it healthy
&
Decreasing the infection
What did competitive exclusion lead to?
Probiotics
What does micro biome mean?
All the microbes in the human body
Does almost every place in our body have microbes?
Yes
Where in the body do you not want microbes in? (2)
Brain & Spinal cord
Where is the most microbes in our body?
GI Tract
What types microbes will you find in blood?
Transient
As long as transient microbes don’t grow in the blood, is it safe?
Yes. As long as it doesn’t grow
What is an opportunistic organism?
They don’t cause disease, however under certain circumstances, they do
When does opportunist microbe knock? Or causes disease? (3)
- Normal flora is destroyed
- Host defenses mechanism compromised
- Normal protective barriers of host are disrupted
What are some examples of opportunists ? (3) and causes ?
( E, S, P,)
E. coli, cause UTI Id moved from intestine to urethra
S. Aureus- causes TSS
Pneumocystis jirocecii - pneumonia in AIDS patients
E. coli is the number one cause of UTI? ( urinary Tract infection )
Yes
What are the 3 evidence of disease? ( the 3 S’s )
Symptoms
Signs
Syndrome
What is symptoms ? Examples
Changes in body functions
Can not be seen, internally
( such as pain and stomach pain )
(Subjective)
What does sign mean? Examples ?
Changes that can be seen
( rash, fever, swelling )
( objective )
What does syndrome mean?
Specific symptoms and signs associated with a disease
What is subjective? Symptoms or signs?
Symptoms
What is objective ? Symptoms or signs?
Signs
Does opportunitistic organisms infect heathly people and how does it effect them?
They can, but they don’t cause disease
Why don’t they cause disease ( opportunities microorganisms ) to healthy people?
Cause they can touch, if someone has a fever
What are the 4 types of diseases? ( infectious ?)
Infectious
Communicable infectious diseases
Non communicable infectious diseases
Non infectious