Epi Cell Bio and the Cell Cycle Flashcards
what si epi
tissue of closely packed cells that forms a surface or lines of cavity or tube
line surfaces
protective
secretary
how ar epi cells classed num layers
num layers
- one - simple or multi (pseudostratfeid)
2/more - stratified
how are epi cells classed by shape
flattened - squamous
cubes - cuboidal
columns - columnar
what si the function of oral mucous epi
protect
perm barrier
protect fluid loss
what si a standard strutter of epi cell
basla lamina hemidesmosome desmosome keratin filaments nu c
what binds two epi cells together
desmosomes - communications done though this also
where is basal lamina
between mesenchyme
and epi
allowing interaction with underlying storm
what is cell rpoliferation
an increase in the number of cells asa result of cell growth and cell divison
wha kind of epi is oral mucosa
stratified squamous epi
wehre is masticatory oral mucosa
gingival and hard palate
keranised
whereis lining oral mucosa
floor mouth
buccal regions
oes non keratinised
where is some specialised oral muscos
dorsum of tongue
both keratinise and non
how does a cell reproduce
by eprfomrig orderly sequence of events which duplicates content then divides into two
what is a simple cell cycle
chromosome replication and cell growth
chromo segregation
cell division
how si the cells cel ontorlled
timer order on off switch robustness adaptability
what re the phases
G1
S
G2
M
what are the cell cycle checkpoints
G1 - enviro fave?
G2 - dna rep
M - chromos on spindle
what are the phases of interphase onwards
prophase metaphase anaphase telophase cytokinesis
what are some cell cycle ‘controllers’
protein kinases
cyclin dept kinases
phosphorylation proteins
what are cyclin dept kinases controlled by
CYCLIN
what happens to cyclins during cell cycle
circle of synthesis
what are cyclin classes
4 classes
- G1/s at end G1 - dna replication
- S bind Cdk’s during s = imitate dna rep
- M - mitosis
what si he cyclin complex for cyclin D
G1/Cdk
what si he cyclin complex for cyclin E
G1-S CdK
cyclins dont only activate cdk but
directs it
what si a growth factor
polypeptides that control animal cel grown and diff
store and rel into ECM
wat is a transcription factor
protein tha regulates the activity of RNA polymerase
what is the proliferation control
receptors
signalling
ECM
phosphorylation
what does a cell proliferation unit have
progenitor cells basal cell layer
divide to clusters
what is cell cycle cyclin over expression always
phsophsyrlaed
what is the guardian of genome
P53
what are stem cels
not terminally diff
divide withoutlimt
each daughter cell has a choice
