Calcium & Bone Flashcards

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1
Q

what is the periodontium

A

tissue around the tooth

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2
Q

what does the periodontium compromise of

A

PDL
alveolar bone
gingiva (gum- incl junctional epi)
—- Cementum?

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3
Q

what are the functions of bone

A

skeletal

  • protection organs
  • rigidity
  • movements
  • attach muscles and teeth

calcium pool
contain marrow

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4
Q

why is it imp to know about bone

A
regional diff in mouth - LA
bone changes in mouth - extraction
ortho tooth moves
osseointegration - implants
biphosphonates
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5
Q

what is the composition of bone

A

65% mineral - HA
25% organic - 90% type 1 collagen an 10% ground subs
10% water

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6
Q

what is the alveolus

A

sac

little cavity

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7
Q

what are the components of the alveolar bone

A

alv bone - cortisol bone compact

basal bone - trabecular bone spongy and cancellous

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8
Q

what is the lamina dura

A

budnelbone
cribriform plate
lining alveolus tooth sits in

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9
Q

what are the lamellae assc with bone

A

circumferential
concentric
interstitial

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10
Q

what are the circumferential lamellae

A

outside of most cortisol bone

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11
Q

what are the concentric lamellae

A

organised in haversian system s- osteon

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12
Q

what are the interstitial lamellae

A

remnants of old lamellae

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13
Q

what are the means of bone formation

A

endochondrol ossification

intramembranous ossification

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14
Q

what is endochondral ossify

A

cartilage –> calcified cart –> bone

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15
Q

what is intramembranous oddification

A

cold of mesenchymal tissue
osteoblasts prod osteoid matrix
woven bone
primary osteon form

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16
Q

what are osteoblasts

A

mesenchymal/ectomesnchymal
bone surface - periosteum/endosteum
prod osteoid matrix

17
Q

what are osteocytes

A

trapped osteoblasts
cell processes
linked by gap junctions
cells vital

18
Q

what are osteoclasts

A

haemopoeitic source - macrophage
large multinuc cells
in how ships lacunae - dissolve bone mineral - acid and break org matrix with enzymes

19
Q

how freuwnet is bone turnover

A

continuous remodelling
resoprton
deposition

20
Q

when is bone completely replaced

A

every 10 years

helps maintain plasma calcium levels

21
Q

how si bone remodelled

A

cutting cone - osteoblasts

filling cone - osteoblasstst

22
Q

what does remodelling result in

A

secondary osteons etc

23
Q

how much calcium in body

A

1kg
99% in bone and teeth
1% body fluids

24
Q

what are roles of calcium

A
mem perm
excitation - contraction
excitation  - secretion
hard tissue form 
blood clots
enzyme rctaion 
in secretions - milk
25
Q

what is quick regulation of calcium regulation

A

rapid exchanges between bone and ECF

26
Q

what is slow regulation go calcium

A

intestinal abs

renal excretions

27
Q

what is parathyroid hormone

A
essential for life
release in response o falling Ca
increases plasma corn of calcium 
prevents hypocalcaemia 
withdraws calcium from bone bank
28
Q

what si the mechanism of PTH

A
fast Ca efflux to plasma 
- osteocytes from labile pool of Ca
slow Ca efflux to plasma 
- bone dissolution
- shift remodelling to favour resorption
- osteoclasts 
kidney 
- reduced excrete of Ca
29
Q

what does pTH deficiency lead to

A

iatrogenic PT gland
tetany
asphyxiation

30
Q

what does PT hormone excess lead to

A

hyperplasia of PT gland
tumours
weak bones
ectopic mineralisation

31
Q

what is calcitonin form

A

c cells on thyroid gland

32
Q

what does calcitonin do

A

prevents calcium conc in plasma becoming high

33
Q

how does calcitonin work

A

reduce osteocyte and osteoclast activity

reduce osteoclast numbers

34
Q

what is vitamin d essential for in tim of Ca

A

Ca in intestine

35
Q

what is vit d

A

prod in skin in response to sunlight on a precursor

increases Ca abs in intestine

36
Q

what is BRONJ

A

biphsophonate related osteonecrosis of the Jaws

37
Q

what are bisphosphonates used for

A

osteoporosis reduce rates

bone metastases

38
Q

hwodoes Bisphophonates work

A

reduce osteoclast activity and reduce bon breakdown

39
Q

what doe BRONJ do

A

impaired bone turnover –> exposed bone after extraction