Enzyme inhibitors Flashcards
How does allopurinol bind
Non covalently
Binds to serine on xanthine oxidase which mimics hypoxanthine
What does allopurinol prevent
Production of uric acid
Aspirin
irreversible, covalent inhibitor
Binds covalently to serine of COX and inhibits production of prostaglandins which cause pain and swelling
How do organophosphates bind
Covalently
What does organophosphates do
Irreversible covalent inhibitor
Binds to sarin nerve gas and pesticides
Binds to serinde residue on acetylcholinesterase
-can’t break down Ach and causes paralysis
What kind of inhibitor is allopurinol
Suicide
What kind of enzyme is penicillin
Suicide, transition state analog
What does penicillin inhibit
glycopeptide aminotransferase
What does penicillin do
Suicide inhibitor
Pretends to be glycopeptide transpeptidase which cleaves bacterial cell wall
Active site serine attacks it and gets stuck
How many carbons does stearic acid have
18 (s)
How many carbons in palmitic acid
16 (p)
Saturated fats are _____ at room temperature
Solid
Which glycerophospholipids is predominantly found on the outer leaflet of the plasma membrane
Phosphatidylcholine
General acid/base catalysts
Glu, His, Asp
Conditional: Lys, Ser, Tyr, Cys, Arg
Covalent catalysts
His, Lys, Ser, Cys
What type of inhibitor is statin
Competitive inhibitor
Treats hypercholesterolemia
V0 is limited by
K3