Entero: Salmonella, Yersinia, Klebsiella, Proteus (Ex2) Flashcards
Intestinal Phase of Salmonella
- non host adapted, gene SPI1
- colonization of ileum and LI
- T3SS, effector proteins into enterocytes
- uptake of Salmonella into enterocytes
- cell lysis
- diarrhea, intestinal damage
- general symptoms
Systemic Phase of Salmonella
- host specific and adapted/restricted, gene SPI2
- intracellular and systemic
- endotoxin and tissue localization
- general symptoms
Salmonella typhimurium in bovines
symptoms
- diarrhea and general symptoms
- tissue localization: abortion and udder
Salmonella dublin in bovines
symptoms in calves and adults
- calf: diarrhea, general symptoms, tissue localization
- adult: diarrhea, general symptoms, organ dependent symptoms (abortion, mastitis)
Treatment of Salmonella in bovines
- isolation of sick animals
- fluid therapy
- antimicrobials
- NSAIDs
Salmonella in Pigs
symptoms, diagnosis, treatment, prevention
- S. choleraesuis: typhoid
- diarrhea and general symptoms, hyperacute (death), acute (cyanosis) chronic (less growth, non-specific)
- diagnosis: culture, ELISA
- treat: antimicrobials, general support
- prevention: management (AI-AO), organic acids, feed composition, vaccination
Salmonella abortus in Horses
- rare, pathogenesis depends on uptake
- treatment: antimicrobials
- diagnosis: bacteriology
Salmonella pullorum
host, symptoms, diagnosis, treatment, other
- chick, turkey, pheasant, younger animals
- typhoid
- high mortality: sepsis, general symptoms, granulomatous lesions, oophoritis
- carriers if survival
- diagnosis: culture, slide agglutination
- treat: antibiotics but no elimination
- reportable
Salmonella gallinarum
- turkey, chickens, ducks, etc., older animals
- typhoid
- reportable
- hyperacute mortality, hemolytic anemia, general symptoms
Salmonella enteriditis
- poultry, zoonotic
- paratyphoid
- consumption of undercook/raw egg
- decreased due to vaccination
Klebsiella general features
habitat, hosts, type
- in water, oil, GI tract, environment
- coliform
- nosocomial infections humans
- opportunistic pathogen
- primates, horses
What does Klebsiella cause in horses, dogs, and cattle?
dogs: pyometra, cystitis
horses: umbilical infections, metritis
cattle: mastitis
Diseases caused by Yersinis pestis in humans/cats
- bubonic plague: local lymphadenitis
- pneumonic plague: pneumonia
- septicemic plague: septicemia
What are the virulence factors of Yersinis pestis?
- capsule
- toxins
- iron acquisition
Describe the pathogenesis of Yersinis pestis
- fleas feed from infected host
- bacteria block flea proventriculus, so it seeks more animals to feed from
- bacteria contaminate feeding site
- survive in macrophages and cause apoptosis
- secrete proteins
- extracellular survival