Enf Parkinson Flashcards

1
Q

Frecuencia

A

2° patologia neurodegenerativa

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2
Q

Fisiopatología Cuerpo Lewy

A

Inclusiones citoplasmáticas eosinofilicas

Compuestas protínas a sinucleína y ubiquitina

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3
Q

Estadios Braak cuantos hay

A

6

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4
Q

Estadios Braak

A

E1-2: Pre sintomas

  Cambios bulbo olfatorio y médula oblongada

E3-4: Migración rostral a SNC y cerebro basal anterior

E5-6: Procesos patológiccos cruzan corteza telencefálica de lóbulos frontales y temporales

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5
Q

FR

A

edad, hombres, genéticos

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6
Q

Genetica

A

SNCA, LRKK, PARK1-2-5, PINK1, DJ

<50 años

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7
Q

Factores protectores (5)

A
  • Vit E y B6
  • AINES
  • Estatinas
  • estrógenos
  • disc grasas saturadas
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8
Q

Clinica

Bradisicinecia + ____ ⚠️

A

Temblor
Rigidez
Alt pustural

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9
Q

Características temblor

A

Unilateral disal -> bilateral
Aum esters
Reposo

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10
Q

Características Rigidez

A

Unilateral

Dentada

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11
Q

Características alt postural

A

manifestación tardia

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12
Q

Dx

A

Clinica

Sx esenciales, se descarte EVC

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13
Q

Criterios apoyo dx

A

Unilateral, asimétrico y respuesta a levodopa

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14
Q

Clasificación estadios

A

0 - 5

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15
Q

Tx

A

Levodopa

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16
Q

2° LINEA

A

aGONISTAS DOPA

Pramipexol y ropinirol

17
Q

E.A Antiparkinsonianos

A

ansiedad, hipotension ortostatica, constipación, insomnio