Endocrine Pharma

Question 1

Mnemonics: 4Bs of thyroid hormone

Answer 1

Brain maturation, Bone growth, Beta-adrenergic effect, inc in BMR

Question 2

Drugs that inhibit peripheral T4 to T3 conversion

Answer 2

PTU, propranolol, hydrocortisone

Question 3

Mnemonics: Drug-induced Hyperthyroidism

Answer 3

CAM

Clofibrate, Amiodarone, Methadone

Question 4

prototype glucocorticoid

Answer 4

hydrocortisone

Question 5

glucocorticoid with highest inflammatory potency

Answer 5

betamethasone

Question 6

mineralocorticoid with highest salt-retaining potency

Answer 6

fludcortisone

Question 7

Mnemonic: Addison vs Conns

Answer 7

ADDisons: ADDrenal insufficiency

Conn’s: adrenal exCess

Question 8

Mnemonics: SE of corticosteroids

Answer 8

Cushingoid:
Cataract, Ulcers, Striae, HTN, Hirsutism, immunosupression, infection, necrosis of femoral head, glucose elevation, osteoporosis, obesity, impaired wound healing, diabetes

Question 9

MOA of biguanides

Answer 9

reduces postprandial and fasting glucose levels

activates AMP-stimulated protein kinase -> inhibition of hepatic and renal gluconeogenesis

Question 10

MOA of Thiazolidinediones

Answer 10

inc target tissue sensitivity to insulin (by activating PPAR-a receptor)
inc gluc uptake in muscle and adipose tissue

Question 11

Thiazolidinediones which inc risk for bladder CA

Answer 11

Pioglitazone

Question 12

Mnemonics: Pioglitazone

Answer 12

pampa-POGI ng insulin para di mo na ma-resist

Question 13

S/Sx of excess PTH

Answer 13

PRAP

painful bones, renal stones, abdominal groans, psychiatric overtones