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07_Pharmacology > Autonomic Pharmacology > Flashcards

Autonomic Pharmacology Flashcards

1
Q

SE of phenylephrine

A

Rebound nasal congestion (Rhinitis medicamentosa)

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2
Q

DOC for alpha-1 agonist ovedose

A

Phentolamine

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3
Q

Why should you avoid pseudoephedrine in 1st trimester?

A

Risk of gastroschisis

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4
Q

Mnemonics for HORNER’s syndrome

A

PAM is HORNY

Ptosis, Anhidrosis, Miosis

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5
Q

counteracts rebound HTN caused by clonidine

A

phentolamine

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6
Q

Drug interaction of clonidine and TCA

A

TCA will dec anti-HTN effect of clonidine due to its alpha-blocking effect

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7
Q

SE of methyldopa

A

Hemolytic anemia (+) coomb’s test

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8
Q

SE of Dobutamine

A

Arrhythmia, tachyphylaxis, eosinophilic myocarditis

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9
Q

Drug class & MOA of Dobutamine

A

Sympathomimetic (beta 1 selective)

activates beta-1 adrenergic receptors

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10
Q

May precipitate intraop floppy iris syndrome in cataract surgery

A

Tamsulosin

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11
Q

What is the pharmacologic advantage of alpha-1 selectivity?

A

Reflex tachycardia is LESS common and LESS severe

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12
Q

Drug class of Isoproterenol

A

nonselective beta agonist

*NOT a beta-blocker

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13
Q

non selecitve beta blocker which masks symptoms of hypoglycemia in diabetics

A

Propranolol

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14
Q

nonselective B blocker which lacks local anesthetic effect and has marked class III antiarrhythmic effects

A

Sotalol

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15
Q

MOA of propranolol in tx of hyperthyroidism

A

Blocks sympathomimetic effect of thyroid hormones

Inhibition of peripheral conversion of thyroxine to triiodothyronine

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16
Q

3 beta-blockers which prolongs survival in MI patients

A

Timolol, Propranolol, Metoprolol

17
Q

3 beta-blockers effective in reducing mortality in CHF px

A

Metoprolol, Bisoprolol, Carvedilol

18
Q

Beta blockers useful in glaucoma

A

Timolol and betaxolol

19
Q

3 beta blockers which are also alpha antagonists

A

Nebivolol, carvedilol, labetolol

20
Q

beta blocker with longest half-life

A

Nadolol

21
Q

Principal CI to beta antagonist use

A

preexisting AV block or cardiac failure not caused by tachycardia

22
Q

B blocker with shortest half life

A

Esmolol

23
Q

MOA of beta antagonists, mannitol, brimonidine, and acetazolamide in glaucoma tx

A

dec production of aqueous humor from ciliary epithelium

24
Q

MOA of pilocarpine in glaucoma tx

A

ciliary muscle contraction, opening of trabecular meshwork -> inc outflow

25
Q

MOA of latanoprost in glaucoma tx

A

inc outflow thru canal of Schlemm

26
Q

MOA of Epi in glaucoma tx

A

inc outflow via uveoscleral veins

07_Pharmacology (13 decks)

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