Autonomic Pharmacology

Question 1

SE of phenylephrine

Answer 1

Rebound nasal congestion (Rhinitis medicamentosa)

Question 2

DOC for alpha-1 agonist ovedose

Answer 2

Phentolamine

Question 3

Why should you avoid pseudoephedrine in 1st trimester?

Answer 3

Risk of gastroschisis

Question 4

Mnemonics for HORNER’s syndrome

Answer 4

PAM is HORNY

Ptosis, Anhidrosis, Miosis

Question 5

counteracts rebound HTN caused by clonidine

Answer 5

phentolamine

Question 6

Drug interaction of clonidine and TCA

Answer 6

TCA will dec anti-HTN effect of clonidine due to its alpha-blocking effect

Question 7

SE of methyldopa

Answer 7

Hemolytic anemia (+) coomb’s test

Question 8

SE of Dobutamine

Answer 8

Arrhythmia, tachyphylaxis, eosinophilic myocarditis

Question 9

Drug class & MOA of Dobutamine

Answer 9

Sympathomimetic (beta 1 selective)

activates beta-1 adrenergic receptors

Question 10

May precipitate intraop floppy iris syndrome in cataract surgery

Answer 10

Tamsulosin

Question 11

What is the pharmacologic advantage of alpha-1 selectivity?

Answer 11

Reflex tachycardia is LESS common and LESS severe

Question 12

Drug class of Isoproterenol

Answer 12

nonselective beta agonist

*NOT a beta-blocker

Question 13

non selecitve beta blocker which masks symptoms of hypoglycemia in diabetics

Answer 13

Propranolol

Question 14

nonselective B blocker which lacks local anesthetic effect and has marked class III antiarrhythmic effects

Answer 14

Sotalol

Question 15

MOA of propranolol in tx of hyperthyroidism

Answer 15

Blocks sympathomimetic effect of thyroid hormones

Inhibition of peripheral conversion of thyroxine to triiodothyronine

Question 16

3 beta-blockers which prolongs survival in MI patients

Answer 16

Timolol, Propranolol, Metoprolol

Question 17

3 beta-blockers effective in reducing mortality in CHF px

Answer 17

Metoprolol, Bisoprolol, Carvedilol

Question 18

Beta blockers useful in glaucoma

Answer 18

Timolol and betaxolol

Question 19

3 beta blockers which are also alpha antagonists

Answer 19

Nebivolol, carvedilol, labetolol

Question 20

beta blocker with longest half-life

Answer 20

Nadolol

Question 21

Principal CI to beta antagonist use

Answer 21

preexisting AV block or cardiac failure not caused by tachycardia

Question 22

B blocker with shortest half life

Answer 22

Esmolol

Question 23

MOA of beta antagonists, mannitol, brimonidine, and acetazolamide in glaucoma tx

Answer 23

dec production of aqueous humor from ciliary epithelium

Question 24

MOA of pilocarpine in glaucoma tx

Answer 24

ciliary muscle contraction, opening of trabecular meshwork -> inc outflow

Question 25

MOA of latanoprost in glaucoma tx

Answer 25

inc outflow thru canal of Schlemm

Question 26

MOA of Epi in glaucoma tx

Answer 26

inc outflow via uveoscleral veins