CNS Drugs

Question 1

MOA of benzo vs barbiturates

Answer 1

FRENzodiazepine: FREquency
BarbiDURates: DURation

Question 2

What abn sleep pattern results from the use of BDZ?

Answer 2

Decreased REM sleep

Question 3

Most effective drug for stopping status epilepticus attacks

Answer 3

Diazepam

Question 4

BDZ longest half life

Answer 4

Chlordiazepoxide

Question 5

DOC seizures in infants

Answer 5

Phenobarbital

Question 6

What is the most catastrophic symptom of sedative-hypnotic withdrawal?

Answer 6

Rebound suicide

Question 7

Mnemonics: Zolpidem

Answer 7

Zzzzzz

Zolpidem, Zaleplon = Zleep DO

Question 8

Mnemonics: Buspirone

Answer 8

Buspirone for Busy People (Always anxious)

Question 9

Mnemonics: Delirium tremens

Answer 9

HAD 48
Hallucinations, Autonomic instability, Delirium
48-72 h post discontinuation

Question 10

DOC delirium tremens

Answer 10

Long-acting DBZ: Diazepam

Question 11

DOC opioid overdose

Answer 11

Naloxone

Question 12

DOC opioid dependence and chronic alcoholism

Answer 12

Naltrexone

Question 13

Mnemonics: What drugs can use dislufiram rxn?

Answer 13

Clara took the Pre-medical Test in PM 
Chlorpropamide 
Cefo-Perazone, Mandole, Tetan 
Procarbazine
Metronidazole

Question 14

DOC for GTC/ partial seizures

Answer 14

Phenytoin

Carbamazepine

Question 15

DOC Trigeminal neuralgia

Answer 15

Carbamazepine

Question 16

DOC for bipolar DO

Answer 16

Valproic acid

Question 17

DOC absence seizures

Answer 17

Ethosuximide

Question 18

ASD with the greatest no of MOA

Answer 18

Topimarate

Question 19

The higher the MAC, the ___ potent of inhaled anesthetics

Answer 19

less

Question 20

The lower the blood:gas partition coefficient is, the ___ the rate of induction/recovery will be

Answer 20

faster

eg. NO, desflurane

Question 21

Lowest potency (highest MAC) and least cardiotoxic among the inhalational anesthetics

Answer 21

NO

Question 22

Only inhaled anesthetic that inc CBF -> inc ICP

Answer 22

NO

Question 23

inhalational anesthetic with SE of coronary steal syndrome

Answer 23

Isoflurane

Question 24

inhalational anesthetic with the highest propensity to cause hepatitis

Answer 24

Halothane

Question 25

Highest potency, lowest MAC among inhalational anesthetics

Answer 25

Methoxyflurane

Question 26

Induction agent of choice for unstable px with min cardipulmonary reserve

Answer 26

Etomidate

Question 27

Antidote to fentanyl

Answer 27

Naloxone

Question 28

IV anesthetic induction of choice

Answer 28

Propofol

Question 29

Mnemonics for IV anesthetics

Answer 29

the mighty king proposes to Oprah | -thiopental, midazolam, ketamine, propofol, opioids

Question 30

Mnemonics: Local Anesthetics

Answer 30

Esters: 1i-procaine, benzocaine Amides: 2is-bupivacaine, ropivacaine, lidocaine

Question 31

Mnemonics: half-life of local anesthetics

Answer 31

Procaine: shortest (PRO finishes fast) Ropivacaine: longest (long ROPe)

Question 32

Why would you not inject local anesthetics into an abscess during I and D?

Answer 32

Lidocaine won't work in an acidic environment (below pKa= charged form will predominate) -> can't cross cell membrane and exert its action

Question 33

Antidote for local anesthetic systemic toxicity

Answer 33

Intralipid

Question 34

All local anesthetics are vasodilators EXCEPT

Answer 34

cocaine

Question 35

Components of EMLA

Answer 35

Eutectic mixture of Local anesthetics | 2.5% prilocaine, 2.5% lidocaine

Question 36

undergoes Hoffman elimination yielding Laudanosine -> seizures

Answer 36

Atracurium

Question 37

3 NMBs considered as DOC for hemodynamically compromised patients

Answer 37

Cisatracurium, vecuronium, rocuronium

Question 38

2Rs of Rocuronium?

Answer 38

Renal and rapid | -good for renal px, rapid onset of action

Question 39

novel chemical antagonist to rocuronium

Answer 39

Suggamadex

Question 40

Drugs used in lethal injection

Answer 40

Thiopental (5g) Pancuronium (100mg) KCl (100 mEq)

Question 41

Mnemonics: Parkison Disease

Answer 41

It's a TRAP | Tremor, Rigidity, Akinesia, Postural instability

Question 42

DOC Parkinson Dse

Answer 42

Levodopa-Carbidopa

Question 43

Mnemonics: Drugs causing livedo reticularis

Answer 43

A man reads FHM and GQ | -Amantadine, Hydroxyurea, Minocycline, Gemcitabine, Quinidine

Question 44

Hard/Positive symptoms of psychosis

Answer 44

Hallucination, Illusion, Delusion, Excitement, Suspiciousness

Question 45

The only antipsychotic with fatal overdose

Answer 45

Thioridazone

Question 46

Has the most muscarinic blockade and has least EPS

Answer 46

Thioridazone

Question 47

Mnemonic: ocular complications of antipsychotics

Answer 47

Chlorpropamide: corneal and lens deposit ThioRidazine: Retinal deposits

Question 48

Causes the most EPS and neuroleptic malignant sx of all typical anti-psychotics

Answer 48

Haloperidol

Question 49

DOC for refractory and suicidal schizophrenia

Answer 49

Clozapine

Question 50

Prototype of all antipsychotics

Answer 50

Chlorpromazine

Question 51

Prototype of atypicals

Answer 51

Clozapine

Question 52

2 atypicals with highest tendency to cause weight gain

Answer 52

Obesity | ClOzapine and Olanzapine

Question 53

Only antipsychotic that reduces risk for suicide

Answer 53

Clozapine

Question 54

Atypicals that are least likely to cause tardive dyskinesia

Answer 54

Quetiapine and Clozapine

Question 55

Why is Clozapine not associated with EPS

Answer 55

bec it blocks the D2C receptor pathway (mesocortical mesolimbic area) not the D2A (nigrostriatal pathway)

Question 56

Mnemonics: Quetiapine

Answer 56

Quetiapine: inc in quiet time

Question 57

with highest propensity for causing hyperPRL among atypicals

Answer 57

Risperidone

Question 58

Only antipsychotic approved for schizophrenia in youth

Answer 58

Risperidone

Question 59

has the greatest risk for QT prolongation among atypicals

Answer 59

Ziprasidone

Question 60

Mnemonics: Neuroleptic Malignant Syndrome

Answer 60

FEVER | -fever, encephalopathy, vitals unstable, elevated CPK, rigidity

Question 61

Mnemonics: SE of lithium

Answer 61

LITHIUM | -low thyroid hormone, heart (ebstein anomaly), inspididus (nephrogenic DI), unintentional mve (tremors)

Question 62

DOC for major depressive DO

Answer 62

Fluoxetine

Question 63

Mnemonics: Erectile dysfunction

Answer 63

A SORE PeniS can't Fuck Hard - SSRIs, opiates, risperidone, ethanol, estrogen - propranolol, spironolactone, finasteride, HCTZ

Question 64

Mnemonics: Features of Serotonin syndrome

Answer 64

FAT CHD - fever, agitation, tremor - clonus, hyperreflexia, diaphoresis

Question 65

What drugs can cause priapism

Answer 65

TIGAS PeniS Qo, AyaW Bumaba! - trazodone, papaverine, sildenafil, quetiapine - alprostadil, warfarin, bupropion

Question 66

Antidepressants not associated with sexual dysfunction

Answer 66

Mirtazapine, Bupripion, Nefazodone

Question 67

Mnemonics: Releasers of NE from presynaptoc vesicles

Answer 67

TAE | -tyramine, amphetamine, ephedrine

Question 68

Which opioids have the shortest and longest half life

Answer 68

Remifentanil= shortest (3-4 mins) | Buprenorphine=longest (4-8 hrs)

Question 69

Prototype opioid

Answer 69

Morphine

Question 70

MnemonicL Morphine SE

Answer 70

MORPHINE | -miosis, out of it, resp dep, pruritus, hypotension headache, in freq, nausea, emesis

Question 71

Side effects of opioids with minimal or no tolerance

Answer 71

Miosis, constipation, convulsion

Question 72

Mnemonics: Cocaine Intoxication

Answer 72

Cocaine: mydriasis