Cancer Chemotherapy

Question 1

wider spectrum of coverage in solid tumors and less renal and GIT side effects, widely use din transplant regimens

Answer 1

Carboplatin

Question 2

part of FOLFOX and FOLFIRI regimen used in tx of tumors resistant to cisplatin and carboplatin in the basis of mismatch repair defect

Answer 2

Oxaliplatin

Question 3

has the highest carcinogenic potential amongst alkylating agent

Answer 3

Procarbazine

Question 4

Mnemonics: Drugs that cause pulmonary fibrosis

Answer 4

BBBAN Me

• bleomycin, busulfan, bromocriptine, amiodarone, nitrofurantoin
• methotrexate

Question 5

Rescue therapy for methotrexate

Answer 5

Leucovorin

Question 6

6-MP metabolism is inhibited by

Answer 6

allopurinol and febuxostat (xanthine oxidase inhibitors)

Question 7

is a chemotx prodrug of FU

Answer 7

Tegafur

Question 8

Mnemonics: Vinca alkaloids

Answer 8

vinBLASTine BLASTs the bone marrow:

vinblastine causes myelosupression

Question 9

MOA and uses of Topotecan

Answer 9

inhibits topoisomerase I

topotecan: 2nd line in advanced ocarian CA, small cell lung CA
irinotecan: metastatic colorectal CA

Question 10

Rescue tx for doxorubicin

Answer 10

Dexrazoxane