Drugs on Smooth Muscles

Question 1

SE of diphenhydramine

Answer 1

Orthostatic hypotension

Question 2

SE of Sumatriptan

Answer 2

Coronary vasospasm

Question 3

Class and MOA of Sumatriptan

Answer 3

5HT1D receptor agonists

Question 4

Class of Ondansetron

Answer 4

5HT3 receptor antagonists

Question 5

Class of Ergotamine vs Ergonovine

Answer 5

Both are 5HT2 receptor antagonist
Ergotamine: vasoselective
Ergonovine: uteroselective

Question 6

Class of Misprostol and Alprostadil

Answer 6

PGE1 analog

Question 7

Class of Dinoprostone

Answer 7

PGE2 analog

Question 8

Class of Carboprost & Latanoprost

Answer 8

PGF2a analog

Question 9

Class and uses of Epoprostenol

Answer 9

PGI2 analog

Pulmonary HTN, reduces platelet aggregation

Question 10

Class and MOA of Sildenafil

Answer 10

Phosphodiesterase 5 inhibitor

inhibits PDE5 which degrades cGMP to inactive GMP -> vasodilation

Question 11

Mnemonics: Longa acting SABAs

Answer 11

FAB C VIOS

Formoterol, Arformeterol, Bambuterol
Cleneterol
Vilanterol, Indacaterol, Olodaterol, Salmeterol

Question 12

Triple tx for asthma-COPD overlap

Answer 12

LAMA + LABA + inhaled ICS

Question 13

Class of Ipratropium

Answer 13

Muscarinic receptor antagonist

Question 14

DOC for asthma prophylaxis

Answer 14

Fluticasone

Question 15

Class and MOA of fluticasone

Answer 15

Corticosteroid

Inhibitor of phospholipase A2

Question 16

Class and MOA of Zileuton

Answer 16

Leukotriene synthesis (Lipooxygenase) inhibitor 
Inhibitor of 5-lipoxygenase

Question 17

Class and MOA of Montelukast

Answer 17

Leukotriene receptor antagonist

Blocks cysteinyl LT-1 receptors for LTC4, D4, E4

Question 18

Class and MOA of Omalizumab

Answer 18

Anti-IgE antibody

Binds IgE antibodies on mast cells