endocrine Pharm MOA and class Flashcards
GnRH anlogs MOA
Synthetic GnRH, mimics action of endogenous hormone when administered in pulsatile manner & inhibits release of anterior pituitary hormones when non-pulsatile administration
GnRH antagonists MOA
With continuous adminstration, binds to hypothalamic receptors and blocks activation of GnRH
GH inhibiting hormone MOA
mimics endogenous action (inhibition of GH)
growth hormone MOA
mimics endogenous action
GH receptor antagonist MOA
binds to GH receptors in the liver WITHOUT activating them
Follicle stimulating Hormone MOA
mixture of FSH and LH
dopamine agonists MOA
decrease prolactin sythesis and secretion through a dopamine-mimic action
vasopressin MOA
mimics endogenous action
vasopressin antagonist
binds to vasopressin receptors WITHOUT activating
thyroid hormone MOA
mimics endogenous action
Tyroid perioxidaseinhibitor MOA
stops the initial step in the synthesis of thyroid hormone
estrogen agents MOA
mimics endogenous action
progesterone and derivatives MOA
mimics endogenous action (as close as possible)
Progestins
profile depending on effects on body, pro gestational, estrogenic, and androgenic
Oragl contraceptive combos (estrogen and progestin)
prevents pregnancy by inhibiting ovulation and decreasing the likelihood of conception and implantation
injectable contraception MOA
prvents follicular maturation and ovulation, causes endometrial thinning
oral contraception MOA
decreases the likelihood of conceptus implantation
morning after pill
prevents fertilization by inhibiting ovulation, thickening of cervix mucosa
abortion pill MOA
strong anti-progestin, blocks action of progesterone, thus ending pregnancy
inhibitors of steroidgenesis MOA
Block one or more of the enzymes involved in the making of sex hormones staring with cholesterol conversion to pregnenolone by cytochrome P450 monooxygenase
Tesosterone
mimics endogenous action
SERM MOA
anti-estrogen, anti-tumor effects
calcium supplements MOA
works with Vit D to build strong bones
Vit D supplements and anlogs MOA
works with calcium to build strong bones
biphosphonates MOA
synthetic analog of pyrophosphonate, natural reglator of bone metabolism
glucocorticoids MOA
mimics endogenous action
inhibition of phospholipase A, rate limiting step in conversion of membrane phospholipid to arachidonic acid
antihyperglacemic agents
mimics endogenous action
synthetic amlin, contributes to glucose control during post prandial periods and insulin mimetic
sulfonylureas
binds to SUR1, closing K channels, thereby opening NA2+ channels, works in presents or absence of glucose
meglitinides MOA
unknown MOA, causes pancreas to release pre-made insulin
biunide MOA
unknown MOA
reduces hepatic glucose outputs increases uptake of glucose by peripheral tissues, including skeletal muscle, lowers both basal and postprandial plasma glucose
TZD MOA
acts by binding gamma peroxizome proliferator-activated receptor and activating it
alpha glucose inhibitors
competitively inhibits intestinal alpha-glucosidase, starch blockers “stacholytic”
glucagon-like peptide-1 agonist MOA
binds to same receptors as glucagon-like peptide 1 and activates
Dipeptidyl-Peptidase (DPP)-4 Inhibitor (Gliptins) MOA
inhibits the enzyme responsible for deactivating incretin
Sodium-glucose co-transporter-2 Inhibitors MOA
Reduce glucose reabsorption in the kidney
Leuprolide (lupron) class
GnRH analogs
Cetrorelix (cetrotide) class
GNH antagonist
Octreotide (sandostain) class
GH inhibiting hormone
somatropin (humatrope) class
growth hormone
Pegisomant (somavert) class
GH receptor antagonist
Menotropin (repronex) class
FSH
Bromocroptin (parlodel) class
dopamine agonist
demopressin (DDVAP) class
vassopressin
conivptan (vaprisol) class
vasopressin antagonist
levothyroxin (synthroid)
thyroid hormone
propylthiouracil (PTU) class
thyroid hormone
methimazole (tapazole)
thyroid hormone
ethinyl estrodiol (estinyl) class
estrogen agents
micronized progestrone (prometrium) MOA
progesterone and derivatives
norerthidrone (aygestin) class
progestins
Norgestimate {Ortho} class
oral contraceptive combo
Norethindrone {Ortho-Novum} class
oral contraceptive combo
Medroxyprogesterone {Depo-Provera} class
Injectable Contraception
Minipill class
oral contraceptive
Levonorgestrel {Plan B} class
morning after pill
Mifepristone {RU 486} class
abortion pill
Tamoxifen {Nolvadex D} class
SERM
Testosterone Gel {Androgel}
testosterone
Teriparatide {Forteo} class
antiosteoporosis
estrogens class
antiosteoporosis
Alendronate {Fosamax} class
Bisphosphonates
Raloxifene {Evista} class
SERM
Cortisol & hydrocortisone class
Glucocorticoids
Insulin {Humulin} class
antihyperglycemic
pramlintide (symlin) class
antihyperglycemic
Tolbutamide {Orinase} class
Sulfonylureas
Repaglinide{Prandin} class
Meglitinides
Metformin {Glucophage}
biguanide
Pioglitazone{Actos} class
Thiazolidinediones (TZD)
Exenatide {Byetta} class
Glucagon-like peptide-1 Agonists
Sitagliptin {Januvia}
Dipeptidyl-Peptidase (DPP)-4 Inhibitor (Gliptins)
Canagliflozin {Invokana} class
Sodium-glucose co-transporter-2 Inhibitors