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Pharmacology > endocrine Pharm MOA and class > Flashcards

endocrine Pharm MOA and class Flashcards

1
Q

GnRH anlogs MOA

A

Synthetic GnRH, mimics action of endogenous hormone when administered in pulsatile manner & inhibits release of anterior pituitary hormones when non-pulsatile administration

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2
Q

GnRH antagonists MOA

A

With continuous adminstration, binds to hypothalamic receptors and blocks activation of GnRH

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3
Q

GH inhibiting hormone MOA

A

mimics endogenous action (inhibition of GH)

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4
Q

growth hormone MOA

A

mimics endogenous action

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5
Q

GH receptor antagonist MOA

A

binds to GH receptors in the liver WITHOUT activating them

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6
Q

Follicle stimulating Hormone MOA

A

mixture of FSH and LH

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7
Q

dopamine agonists MOA

A

decrease prolactin sythesis and secretion through a dopamine-mimic action

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8
Q

vasopressin MOA

A

mimics endogenous action

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9
Q

vasopressin antagonist

A

binds to vasopressin receptors WITHOUT activating

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10
Q

thyroid hormone MOA

A

mimics endogenous action

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11
Q

Tyroid perioxidaseinhibitor MOA

A

stops the initial step in the synthesis of thyroid hormone

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12
Q

estrogen agents MOA

A

mimics endogenous action

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13
Q

progesterone and derivatives MOA

A

mimics endogenous action (as close as possible)

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14
Q

Progestins

A

profile depending on effects on body, pro gestational, estrogenic, and androgenic

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15
Q

Oragl contraceptive combos (estrogen and progestin)

A

prevents pregnancy by inhibiting ovulation and decreasing the likelihood of conception and implantation

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15
Q

injectable contraception MOA

A

prvents follicular maturation and ovulation, causes endometrial thinning

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16
Q

oral contraception MOA

A

decreases the likelihood of conceptus implantation

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17
Q

morning after pill

A

prevents fertilization by inhibiting ovulation, thickening of cervix mucosa

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18
Q

abortion pill MOA

A

strong anti-progestin, blocks action of progesterone, thus ending pregnancy

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19
Q

inhibitors of steroidgenesis MOA

A

Block one or more of the enzymes involved in the making of sex hormones staring with cholesterol conversion to pregnenolone by cytochrome P450 monooxygenase

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20
Q

Tesosterone

A

mimics endogenous action

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21
Q

SERM MOA

A

anti-estrogen, anti-tumor effects

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22
Q

calcium supplements MOA

A

works with Vit D to build strong bones

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23
Q

Vit D supplements and anlogs MOA

A

works with calcium to build strong bones

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24
Q

biphosphonates MOA

A

synthetic analog of pyrophosphonate, natural reglator of bone metabolism

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25
Q

glucocorticoids MOA

A

mimics endogenous action
inhibition of phospholipase A, rate limiting step in conversion of membrane phospholipid to arachidonic acid

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26
Q

antihyperglacemic agents

A

mimics endogenous action
synthetic amlin, contributes to glucose control during post prandial periods and insulin mimetic

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27
Q

sulfonylureas

A

binds to SUR1, closing K channels, thereby opening NA2+ channels, works in presents or absence of glucose

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28
Q

meglitinides MOA

A

unknown MOA, causes pancreas to release pre-made insulin

29
Q

biunide MOA

A

unknown MOA
reduces hepatic glucose outputs increases uptake of glucose by peripheral tissues, including skeletal muscle, lowers both basal and postprandial plasma glucose

30
Q

TZD MOA

A

acts by binding gamma peroxizome proliferator-activated receptor and activating it

31
Q

alpha glucose inhibitors

A

competitively inhibits intestinal alpha-glucosidase, starch blockers “stacholytic”

32
Q

glucagon-like peptide-1 agonist MOA

A

binds to same receptors as glucagon-like peptide 1 and activates

33
Q

Dipeptidyl-Peptidase (DPP)-4 Inhibitor (Gliptins) MOA

A

inhibits the enzyme responsible for deactivating incretin

34
Q

Sodium-glucose co-transporter-2 Inhibitors MOA

A

Reduce glucose reabsorption in the kidney

35
Q

Leuprolide (lupron) class

A

GnRH analogs

36
Q

Cetrorelix (cetrotide) class

A

GNH antagonist

37
Q

Octreotide (sandostain) class

A

GH inhibiting hormone

38
Q

somatropin (humatrope) class

A

growth hormone

39
Q

Pegisomant (somavert) class

A

GH receptor antagonist

40
Q

Menotropin (repronex) class

41
Q

Bromocroptin (parlodel) class

A

dopamine agonist

42
Q

demopressin (DDVAP) class

A

vassopressin

43
Q

conivptan (vaprisol) class

A

vasopressin antagonist

44
Q

levothyroxin (synthroid)

A

thyroid hormone

45
Q

propylthiouracil (PTU) class

A

thyroid hormone

46
Q

methimazole (tapazole)

A

thyroid hormone

47
Q

ethinyl estrodiol (estinyl) class

A

estrogen agents

48
Q

micronized progestrone (prometrium) MOA

A

progesterone and derivatives

49
Q

norerthidrone (aygestin) class

A

progestins

50
Q

Norgestimate {Ortho} class

A

oral contraceptive combo

51
Q

Norethindrone {Ortho-Novum} class

A

oral contraceptive combo

52
Q

Medroxyprogesterone {Depo-Provera} class

A

Injectable Contraception

53
Q

Minipill class

A

oral contraceptive

54
Q

Levonorgestrel {Plan B} class

A

morning after pill

55
Q

Mifepristone {RU 486} class

A

abortion pill

56
Q

Tamoxifen {Nolvadex D} class

57
Q

Testosterone Gel {Androgel}

A

testosterone

58
Q

Teriparatide {Forteo} class

A

antiosteoporosis

59
Q

estrogens class

A

antiosteoporosis

60
Q

Alendronate {Fosamax} class

A

Bisphosphonates

61
Q

Raloxifene {Evista} class

62
Q

Cortisol & hydrocortisone class

A

Glucocorticoids

63
Q

Insulin {Humulin} class

A

antihyperglycemic

64
Q

pramlintide (symlin) class

A

antihyperglycemic

65
Q

Tolbutamide {Orinase} class

A

Sulfonylureas

66
Q

Repaglinide{Prandin} class

A

Meglitinides

67
Q

Metformin {Glucophage}

68
Q

Pioglitazone{Actos} class

A

Thiazolidinediones (TZD)

69
Q

Exenatide {Byetta} class

A

Glucagon-like peptide-1 Agonists

70
Q

Sitagliptin {Januvia}

A

Dipeptidyl-Peptidase (DPP)-4 Inhibitor (Gliptins)

71
Q

Canagliflozin {Invokana} class

A

Sodium-glucose co-transporter-2 Inhibitors

Pharmacology (13 decks)

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