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Pharmacology > endocrine Pharm MOA and class > Flashcards

endocrine Pharm MOA and class Flashcards

1
Q

GnRH anlogs MOA

A

Synthetic GnRH, mimics action of endogenous hormone when administered in pulsatile manner & inhibits release of anterior pituitary hormones when non-pulsatile administration

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2
Q

GnRH antagonists MOA

A

With continuous adminstration, binds to hypothalamic receptors and blocks activation of GnRH

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3
Q

GH inhibiting hormone MOA

A

mimics endogenous action (inhibition of GH)

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4
Q

growth hormone MOA

A

mimics endogenous action

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5
Q

GH receptor antagonist MOA

A

binds to GH receptors in the liver WITHOUT activating them

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6
Q

Follicle stimulating Hormone MOA

A

mixture of FSH and LH

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7
Q

dopamine agonists MOA

A

decrease prolactin sythesis and secretion through a dopamine-mimic action

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8
Q

vasopressin MOA

A

mimics endogenous action

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9
Q

vasopressin antagonist

A

binds to vasopressin receptors WITHOUT activating

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10
Q

thyroid hormone MOA

A

mimics endogenous action

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11
Q

Tyroid perioxidaseinhibitor MOA

A

stops the initial step in the synthesis of thyroid hormone

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12
Q

estrogen agents MOA

A

mimics endogenous action

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13
Q

progesterone and derivatives MOA

A

mimics endogenous action (as close as possible)

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14
Q

Progestins

A

profile depending on effects on body, pro gestational, estrogenic, and androgenic

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15
Q

Oragl contraceptive combos (estrogen and progestin)

A

prevents pregnancy by inhibiting ovulation and decreasing the likelihood of conception and implantation

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15
Q

injectable contraception MOA

A

prvents follicular maturation and ovulation, causes endometrial thinning

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16
Q

oral contraception MOA

A

decreases the likelihood of conceptus implantation

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17
Q

morning after pill

A

prevents fertilization by inhibiting ovulation, thickening of cervix mucosa

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18
Q

abortion pill MOA

A

strong anti-progestin, blocks action of progesterone, thus ending pregnancy

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19
Q

inhibitors of steroidgenesis MOA

A

Block one or more of the enzymes involved in the making of sex hormones staring with cholesterol conversion to pregnenolone by cytochrome P450 monooxygenase

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20
Q

Tesosterone

A

mimics endogenous action

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21
Q

SERM MOA

A

anti-estrogen, anti-tumor effects

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22
Q

calcium supplements MOA

A

works with Vit D to build strong bones

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23
Q

Vit D supplements and anlogs MOA

A

works with calcium to build strong bones

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24
biphosphonates MOA
synthetic analog of pyrophosphonate, natural reglator of bone metabolism
25
glucocorticoids MOA
mimics endogenous action inhibition of phospholipase A, rate limiting step in conversion of membrane phospholipid to arachidonic acid
26
antihyperglacemic agents
mimics endogenous action synthetic amlin, contributes to glucose control during post prandial periods and insulin mimetic
27
sulfonylureas
binds to SUR1, closing K channels, thereby opening NA2+ channels, works in presents or absence of glucose
28
meglitinides MOA
unknown MOA, causes pancreas to release pre-made insulin
29
biunide MOA
unknown MOA reduces hepatic glucose outputs increases uptake of glucose by peripheral tissues, including skeletal muscle, lowers both basal and postprandial plasma glucose
30
TZD MOA
acts by binding gamma peroxizome proliferator-activated receptor and activating it
31
alpha glucose inhibitors
competitively inhibits intestinal alpha-glucosidase, starch blockers "stacholytic"
32
glucagon-like peptide-1 agonist MOA
binds to same receptors as glucagon-like peptide 1 and activates
33
Dipeptidyl-Peptidase (DPP)-4 Inhibitor (Gliptins) MOA
inhibits the enzyme responsible for deactivating incretin
34
Sodium-glucose co-transporter-2 Inhibitors MOA
Reduce glucose reabsorption in the kidney
35
Leuprolide (lupron) class
GnRH analogs
36
Cetrorelix (cetrotide) class
GNH antagonist
37
Octreotide (sandostain) class
GH inhibiting hormone
38
somatropin (humatrope) class
growth hormone
39
Pegisomant (somavert) class
GH receptor antagonist
40
Menotropin (repronex) class
FSH
41
Bromocroptin (parlodel) class
dopamine agonist
42
demopressin (DDVAP) class
vassopressin
43
conivptan (vaprisol) class
vasopressin antagonist
44
levothyroxin (synthroid)
thyroid hormone
45
propylthiouracil (PTU) class
thyroid hormone
46
methimazole (tapazole)
thyroid hormone
47
ethinyl estrodiol (estinyl) class
estrogen agents
48
micronized progestrone (prometrium) MOA
progesterone and derivatives
49
norerthidrone (aygestin) class
progestins
50
Norgestimate {Ortho} class
oral contraceptive combo
51
Norethindrone {Ortho-Novum} class
oral contraceptive combo
52
Medroxyprogesterone {Depo-Provera} class
Injectable Contraception
53
Minipill class
oral contraceptive
54
Levonorgestrel {Plan B} class
morning after pill
55
Mifepristone {RU 486} class
abortion pill
56
Tamoxifen {Nolvadex D} class
SERM
57
Testosterone Gel {Androgel}
testosterone
58
Teriparatide {Forteo} class
antiosteoporosis
59
estrogens class
antiosteoporosis
60
Alendronate {Fosamax} class
Bisphosphonates
61
Raloxifene {Evista} class
SERM
62
Cortisol & hydrocortisone class
Glucocorticoids
63
Insulin {Humulin} class
antihyperglycemic
64
pramlintide (symlin) class
antihyperglycemic
65
Tolbutamide {Orinase} class
Sulfonylureas
66
Repaglinide {Prandin} class
Meglitinides
67
Metformin {Glucophage}
biguanide
68
Pioglitazone {Actos} class
Thiazolidinediones (TZD)
69
Exenatide {Byetta} class
Glucagon-like peptide-1 Agonists
70
Sitagliptin {Januvia}
Dipeptidyl-Peptidase (DPP)-4 Inhibitor (Gliptins)
71
Canagliflozin {Invokana} class
Sodium-glucose co-transporter-2 Inhibitors

Pharmacology (13 decks)

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