Endocrine Drugs

Question 1

Cushing syndrome

Answer 1

High cortisol
S/S- weight gain around face and upper back, fat loss from arm and feet, weight gain around stomach, high Bp,

Question 2

Thiazolidinediones
Glita to the pparty

Answer 2

Binds to peroxisome proliferator activated receptor gamma

Insulin sensitizer
Pioglitazone, Rosiglitazone
As with metformin, they can cause ovulation to resume in premenopausal women with PCOS
A/E heart failure, increased risk fractures & osteopenia
Pioglitazone- increased risk of bladder cancer
Rosiglitazone- cardiac problems

Question 3

GLP 1 agonist
Gulping ‘tide’ pods is not safe

Answer 3

Incretin mimetics

Treat type 2 diabetes and promotes weight loss
Semaglutide, Liraglutide, exenatide
A/E pancreatitis

Question 4

SGLT 2 inhibitors
Flowzin through the urine

Answer 4

Dapagliflozon, empagliflozin, canagliflozin

A/E- glucosuria, dehydration, hyperkalamia, vaginal yeast infection

Question 5

Alpha glucosidase inhibitors
Acarb=without carb

Answer 5

Acarbose
A/E- bloating, gas, GI upset

Question 6

Amylin analogues

Answer 6

Pramlintide
Works with insulin
A/E hypoglycaemia

Question 7

DPP 4 inhibitors
Liptin makes you pp 4 more times

Answer 7

Saxagliptin, sitagliptin, linagliptin
A/E- urinary and respiratory tract infection

Question 8

Meglitinides
Similar to SU

Answer 8

Nateglinide, repaglinide
A/E hypoglycaemia

Question 9

Sulfonylureas
I’de take my SU

Answer 9

Increase insulin release by opening Ca2+ and blocking K+
Glimeperide, glyburide, glipizide
A/E hypoglycaemia, disulfuram like reactions

Displace coumadin from protein leading to toxicities of warfarin

Question 10

Metformin

Answer 10

Used in PCOS as well
Increase glycolysis, glucose uptake and inhibit gluconeogensis

A/E metabolic acidosis, vitamin B12 deficiency

When contrast in diagnosis is used together with metformin, renal function is affected

Question 11

Propylthiouracil

Answer 11

Inhibit iodide oxidation and iodouracil coupling

DOA in 1st trimester, thyroid storm

A/E- severe liver injury (BBW), agranulocytosis, dermatologic reactions, GI upset

Question 12

Methimazole

Answer 12

DOA in 2nd and 3rd trimester

A/E less liver injury, dermatologic reaction, agranulocytosis

Question 13

Cabergoline

Answer 13

Dopamine D2 agonist
Used in treatment of hyperprolactinaemia

Question 14

Amylin analog

Answer 14

Pramlintide

Inhibits postprandial glucagon release,Improves satiety

When given with insulin, reduce insulin dose to 50%

Avoided in gastroparesis patients