Antibiotics

Question 1

Macrolides
Protein synthesis inhibitors(50S)

Answer 1

Bacteriostatic, used for patients allergic to penicillin

Azithromycin, erythromycin, clarithromycin

A/E- GI disturbance, Ototoxicity

Question 2

Chloramphenicol

Answer 2

Binds to 50S ribosomal subunit reversibly

A/E- grey baby syndrome (can’t glucoronidate due to poor renal development.),
anaemia(g6p dehydrogenase deficiency),
Interacts with warfarin and phenytoin

Question 3

Aminoglycosides

Answer 3

Bactericidal, broad spectrum but narrow TI, given parenterally

Gentamicin, neomycin, tobramycin

A/E Ototoxicity, nephrotoxicity

Question 4

Flouroquinolones

Answer 4

Nosocomial infections, Pseudononas aeruginosa(severe resistant infection)

Ciprofloxacin, levofloxacin, norfloxacin

A/E Achilles tendon rupture in <18yrs