Adrenergic Flashcards
1
Q
Cathecolamines
A
Metabolised by
MAO (intraneural, gut, liver)
COMT (gut, post synapse) so short acting and not given orally
Poor CNS penetration due to polarity
2
Q
Non catecholamines
A
Eg amphetamine, ephedrine, phenylephrine
Increased lipid solubility due to lack of hydroxyls , longer duration (not metabolized by MAO and COMT