Adrenergic Flashcards

1
Q

Cathecolamines

A

Metabolised by
MAO (intraneural, gut, liver)
COMT (gut, post synapse) so short acting and not given orally

Poor CNS penetration due to polarity

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2
Q

Non catecholamines

A

Eg amphetamine, ephedrine, phenylephrine
Increased lipid solubility due to lack of hydroxyls , longer duration (not metabolized by MAO and COMT

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