endocrine Flashcards
most common site of ectopic thyroid tissue
tounge
anterior midline neck mass that moves with swallowing
thyroglossal duct cyst
secrets aldosterone
zone glomerulosa (outer adrenal cortex)
secrets cortisol and sex hormones
zona fasisculata (middle adrenal cortex)
secretes androgens
zona reticulalaris (inner adrenal cortex)
secretes catccholamines
adernal medulla
drains into IVC via renal vein
left adrenal gland
posterior pituitary secretes
ADH and oxytocin
anterior pituitary secretes
FSH, LH,ACTH, TSH,prolactin, GH, melanotropin
alpha pancreas cells release
glucagon
delta pancreas cells release
somatpstain
expresses GLUT-1
RBC’s, Brain
insulan dependant GLUT receptors
4 (on adipose and skeletal muscle)
anabolic functions of insulin
glucose transport into skeletal muscle and adipose
glycogen and TG synth/storage
Na retention
Protein synth
cellular uptake of K+ and amino acids
glucagon release
always dependant for glucose
RBCs (lack mitochondira for anerobic metabolism)
catabolic effects of glucogon
glycogennolysis, gluconeogenisis, lipilysis and ketone production
downregulates prolactin
dopamine
downregulates GH and TSH
somatostatin
downregulates GnRH
prolactin
17a-hydroxylase deficiency presents
high mineralcorticoids, low cortisol, low sex hormones
hypertension, hypokalemia
XY with low DHT
pseudohermaphroditism
XX with 17a-hydroxylase deficiency
external phenotypical female with normal internal sex organs, lacking secondary sex charecteristics
21 hydroxalase deficiency (most common) presents as
low mineralcorticoids, low cortisol, high sex hormones
hypotension, hyperkalemia, hi renin and volume depletion
masculization, eading to pseudoherm in females
11B - hydroxylase def presents as
low aldosterone, low cortisol, high sex hormones.
hypertension and msculizization
cortisol effects
maintains BP lowers bone formation anti inflammatory immunosuppressive raises insulin resistance increases gluconeoenisis, liposyisis, inhibits fibroblasts (striae)
function of PTH
increases serum calcim
decreses phosphate reabsorption in DCT
secretes calcitonin
parafolicular (C cells) of thyroid
function of calcitonin
opposes PTH, lowers serum Ca++