basic embryology Flashcards
function of sonic hedgehog gene
patterning along anterior/posterior axis. incoved in CNS development
function of wnt-7 gene
proper orginization along dorsal-ventral axis
funtion of FGF gene
stimulates underling mesoderm - lengthens limbs
function of Hox genes
segmental orginization of embryo in crainocaudal direction - mutations result in appendages in the wrong locations
time of first HCG secretion
week one
bilaminar disk formation time
week 2
time neural tube forms and closes
3-8 weeks
when heart begins to beat
4 weeks
when limb buds start to form
4 weeks
when genatalia start to take on charecteristcs
10 weeks
orininates from surface ectoderm
adenohyophosis, lens of eye, epithelial linings of oral cavity, sensory organs of ear, epidermis, parotid, sweat and mammary glands
originates from neuroectoderm
brain, retina, optic nerve, spinal cord
orginates from neural crest
PNS, melanocytes, chromaffin cells of adrenal medulla, C cells of thyroid, bones of skull, teeth, aorticopulmonary septum
originates from mesoderm
muscle, bone, connective tissue, serous linings of body cavities, spleen, CV structures, lymphatics, blood, wall of gut tube, kidneys, wall of bladder, vagina, dermis, testes, ovaries
originates from endoderm
gut tube epithelium, lungs, liver, galbladder, pancreas, thymus, PTH, thyroid follicular cells
Birth defect caused by ACEi
renal damage
Birth defect caused by alkylating agents
abcense of digits,
Birth defect caused by aminoglycosides
CN VIII tox
Birth defect caused by carbamaxepine
neuro tube defects, craniofacial defects, development delay
Birth defect caused by DES
vaginal cleat cell cancer, congenital mullerian anamolaies
Birth defect caused by folate antagonists
neural tube defects
Birth defect caused by lithium
ebstein’s anomaly (atrialized RV)
Birth defect caused by phenytoin
microcephaly, dysmorphic craniofacial features, hypoplastic nails, and distal phalenges, cardiac defects
Birth defect caused by tetracyclines
discolored teeeth
