Endocrine 3: Receptors and Signalling Flashcards
describe how hormones signal
t/f: one receptor can have multiple ligands
t/f: one ligand can have multiple receptors
What does it mean for cell receptors to be saturable?
What are four properties of receptors? explain each
What is the difference in the binidng of intracellular vs cell membrane signal receptors?
What do intracellular receptors do to genes?
What are the four plasma membrane receptors?
What receptors do peptide hormones engage with?
What rceeptors do steroid hormones engage with?
How do pep hormones generate metabolic effects?
How do steroid hormones generate metabolic effects?
What are two ways in which lipopillic messengers can create proteins?
What are hormone response elements?
How do GPCRs work?
How do enzyme receptors work?
How do ion channels work?
What do GPCRs do upon activation?
explain how a GCPR works with adenylyl cyclase to generate a cellular response
Explain what signal amplification is and how it occurs
Explain how Gq and phospolipase c generate a cellular response
how does Galphai inactivate adenylyl cyclase
What are the three types of g proteins
what is the target and activity of Gs
what is the target and activity of Gq
what is the target and activity of Gi
What happens during fight or flight to the liver, fat, heart, skeletal muscle blood vessels, and intestine/skin/kidney
What type of receptor is on intesinal blood vessels versus skeletal blood vesssels
Epi and alpha receps produce what response?
epi and beta2 receps produce what response?
what happens when Gs is activated
what happens when Gi is activated
what happens when Gq is activated
how can you modulate hormone signalling (6)
explain how receptors get recycled
