Endocrine Flashcards
Endocrine derived from the greek words
endo - within
krino - secrete
Composed of endocrine glands and specialized endocrine cells located throughout the body.
Endocrine system
Endocrine glands secrete chemical messengers called “____” into the bloodstream in order to produce a specific response to ____
hormones
target tissues or effectors.
Hormones derived from the Greek word
Hormon - to set in motion
hormones has two chemical categories
- Lipid- soluble
- Water-soluble
• Non-polar
• Small size and low solubility
in aqueous fluids.
Lipid- soluble hormones
• Polar
• Vary from small to large and
soluble in blood
Water-soluble hormones
Receptor Location: Nucleus or cytoplasm
Lipid-soluble hormones
• ReceptorLocation:Plasma membrane’s outer surface
Water-soluble hormones
Needs a binding protein for transport
Lipid-soluble hormones
dissolvedirectly into the blood and are delivered to the target tissue without attaching to binding protein.
Large hormones
need attachment to larger protein to avoid being filtered out of the blood.
Small hormones
There are three types of stimuli which regulate hormone release
- Humoral 2. Neural
- Hormonal
Blood-borne chemicals which stimulate release of some hormones are called
humoral stimuli
It occurs when a secreted hormone stimulates the secretion of other hormones. These hormones are called
Tropic hormones
There are hormones that prevents the secretion of other hormones. These hormones are called
“inhibiting hormones.”
Hormone release caused by altered levels of certain critical ions or nutrients.
Humoral stimulus
Hormone release caused by neural input.
Nueral stimulus
Hormone release caused by another hormone (a tropic hormone).
Hormonal stimulus
consists of ductless glands
Endocrine system
The following are the endocrine glands and organs:
- Pituitary gland
- Thyroid gland
- Parathyroid gland
- Adrenal glands
- Pancreas
- Testes and Ovaries
- Thymus
- Pineal Gland
The pituitary gland is also called the
Hypophysis
It is a small gland about the size of a pea.
Pituitary gland
It rest in a depression of the sphenoid bone inferior to the hypothalamus of the brain.
Pituitary gland
attached to the hypothalamus by this structure.
Infudibulum
2 parts of pituitary gland
• Anterior pituitary • Posterior pituitary
The thyroid gland is made up of two lobes connected by a narrow band called
Isthmus
One of the largest endocrine glands.
Thyroid gland
Appears more red than surrounding tissues.
Thyroid Gland
Main function: Secretion of thyroid hormones
Thyroid Gland
are synthesized and stored within the thyroid follicles.
Thyroid hormones
thyroid follicles contain protein called “_____” in which hormones are attached.
thyroglobulin
The synthesized hormones in thyroid follicles are
thyroxine/tetraiodothyronine(T4) and triiodothyronine (T3)
Thyroid hormones have a negative feedback effect on the
hypothalamus and pituitary gland.
Loss of negative feedback will result in excess TSH. It causes enlargement of the thyroid. This condition is called
Goiter
lack of thyroid hormones
Hypothyroidism
Hypothyroidism, In infants, it can result in
Cretinism
Hypothyroidism, In adults, it can result to
decreased metabolic rate, sluggishness, reduced ability to perform routine tasks and myxedema.
elevated rate of thyroid hormones
Hyperthyroidism
a type of of hyperthyroidism that results when the immune system produces abnormal proteins that are similar in structure and function to TSH.
Grave’s Disease
Four glands embedded in the posterior wall of the thyroid gland.
Parathyroid Gland
These glands secrete the parathyroid hormone
Parathyroid Gland
essential in regulation of calcium level.
parathyroid hormone
Two small glands located superior to each kidney.
Adrenal glans
Each adrenal gland has an inner part called the
Adrenal medulla
Each adrenal gland has an outer part called
Adrenal cortex
The principal hormone released by the adrenal medulla is
Epinephrine
The adrenal cortex secretes three classes of steroid hormones:
1)mineralocorticoids 2)glucocorticoids 3)androgens
regulatesbloodvolume and levels of potassium and sodium ions.
Mineralocorticoids
Major hormone of Mineralocorticoids
Aldosterone
Binds to receptor molecules in the kidney, but it also affects the intestine, sweat glands and salivary glands.
Aldosterone
causes sodium ions and water to be retained in the body.
Aldosterone
regulates blood nutrient levels.
Glucocorticoids
Major hormone of Glucocorticoids
Cortisol
Responds in stressful situations
Cortisol
Increases the breakdown of proteins and lipids. It also increases their conversion to forms of energy the body can use.
Cortisol
Reduces inflammatory and immune responses.
Cortisone
Stimulate the development of male sexual characteristics.
Androgens
both male and female possess these hormones.
Androgens
Abnormally high level of hormone that can exaggerate male characteristics in both male and female.
Androgens
Consists of the pancreatic islets (Islets of Langerhans).
Pancreas
islets secrete three hormones:
1)insulin 2)glucagon and 3)somatostatin
has an essential role in maintaining homeostasis.
Blood glucose
will cause tissues to break down lipids and proteins to provide an alternative source of energy.
A decreased blood glucose
• As lipids break down, the liver converts fatty acids to ketones. As a result, it can occur
Acidosis
The kidneys produce large volume of urine containing substantial amount of glucose. However, dehydration can result because of rapid loss of water in the form of urine.
Increased blood glucose level
Released from the beta cells
Insulin
Major target tissues of insulin
liver, adipose tissue, muscle and satiety area of hypothalamus.
Occurs when too little insulin is secreted from the pancreas.
Type1DiabetesMellitus
Occurs when lack of number of insulin receptors on target cells or defective target cells do not respond normally to insulin.
Type 2 Diabetes Mellitus
Released from the alpha cells
Glucagon
Binds to membrane-bound receptors of the liver, causing glycogen to convert to glucose.
Glucagon
released into the bloodstream
Glucose
Released from the delta cells
Somatostatin
are structures of the reproductive tract which has an essential role in reproduction.
Testes and ovaries
The male sex hormone is
Testosterone
The female sex hormones are
Estrogen and progesterone
lies in the upper part of the thoracic cavity which functions in immunity.
Thymus
Thymus secretes the hormone “___” which aids in the development of the T-cells.
thymosin
is a small, pinecone-shaped structure located superior and posterior to the thalamus of the brain.
Pineal gland
This produces the hormone “melatonin” which decreases secretion of LH and FSH
Pineal glands