Embryology 2 Flashcards

1
Q

What cells make the trophoblast

A
  • Cytotrophoblast

- Syncytiotrophoblast

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2
Q

What do cytotrophoblast & syncytiotrophoblast help the trophoblast with

A

Implantation

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3
Q

What cells make the embryoblast

A
  • Hypoblast

- Epiblast

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4
Q

Why doesn’t the mother’s immune system attack the blastocyst

A
  • Syncytiotrophoblast release substances which hide it from IS
  • Multinucleated cells formed
  • No gaps for immune cells to get to embryo
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5
Q

What is the first stage of organisation of the body plan

A

Bilaminar formation

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6
Q

What is the significance of the bilaminar

A
  • Bilinear

- Established dorsal & ventral axis

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7
Q

Why bilinear

A

Two embryoblast cells

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8
Q

Which cells form the ventral aspect of embryo

A

Hypoblasts

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9
Q

Which cells form the dorsal aspect of embryo

A

Epiblasts

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10
Q

How does amniotic cavity form

A

Small fluid-filled cavity in epiblasts

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11
Q

When does full implantation take place

A

Day 9

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12
Q

What happens in full implantation

A
  • Migration of hypoblast cells encase blastocyst cavity

- Primary yolk sac forms

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13
Q

When does the coagulation plug form

A

Full implantation

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14
Q

What is the function of the coagulation plug

A

Protect blastocyst on uterine lining

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15
Q

How does embryoblast receive nutrients if no placental circulation happening yet

A

Diffusion of nutrients via uterine gland

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16
Q

How is the uteroplacental circulation established

A

Syncytiotrophoblast erodes walls of maternal capillaries

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17
Q

Where do the different cells receive their nutrients from

A

Trophoblastic lacuna

18
Q

What is the extraembryonic mesoderm

A

Layer of connective tissue derived from yolk sac cells

19
Q

When is extraembryonic mesoderm formed

A

Simultaneously with uteroplacental circulation

Days 10-11

20
Q

Where is extraembryonic mesoderm formed

A

Between 1ry yolk sac & cytotrophoblast

21
Q

When extraembryonic mesoderm is fully developed what does it cover

A

Amniotic cavity

22
Q

When does blastocyst receive blood supply

A

When trophoblast breaks down the capillary wall

23
Q

What forms and grows in the extraembryonic mesoderm

A

Chrionic cavity

24
Q

When does chrionic cavity form

A

Days 12-13

25
Q

When is 2ry (definitive) yolk sac formed

A

Days 12-13

26
Q

How is the 2ry yolk sac formed

A

2nd wave of hypoblast cells migrating

27
Q

Where are the amniotic cavity & 2ry yolk sac suspended

A

Chronic cavity by connecting stalk

28
Q

What forms the bilamina disc

A

Embryonic sac & definitive yolk sac

29
Q

What is the fate of the connecting stalk

A

Forms umbilical cord

30
Q

What hormones do syncytiotrophoblast secrete

What is its function

What is it helpful for

A

Human chronic gonadotrophin - hCG

  • Maintains endometrium
  • Role in maternal immunotolerence

Pregnancy testing

31
Q

How frequent is abnormal implantation sites

A
  • 2% of pregnancies

- 9% of pregnancy-related deaths

32
Q

What is placenta Previn

A

When placenta block vagina

33
Q

What can placenta Persia cause

A

Severe bleeding in late pregnancy

34
Q

Where do the majority of ectopic pregnancies happen

A

Uterine tube

35
Q

How can abdominal implantation happen

A

Zygote entering the gap between ovary & uterine tube

36
Q

When does lithopaedion occur

A

When abdominal pregnancy remains undiagnosed

37
Q

How does baby die in lithopaedion

A

Too large to be reabsorbed —> calcifies

38
Q

Why does foetus calcify in lithopaedion

A

Protect mother from its necrotic tissue

39
Q

What is the hydatidiform mole

A

Development of trophoblast without embryonic tissue

40
Q

What causes hydatidiform mole

A

Fertilisation of an empty egg

41
Q

Explain parental imprinting in relation to hydatidiform mole

A

Parental genes favour formation of trophoblast at the expense of embryo

42
Q

Why does hydatidiform mole still make you think someone is pregnant

A

Syncytiotrophoblast produces hCG —> +ve pregnancy test