Elimination Flashcards
The basic unit of the Kidney
The nephron
What is the glomerulus?
Cluster of capillaries that filter blood into the Bowman’s capsule
What is GFR?
Glomerular Filteration Rate
90-120 ml/min
GFR is directly related to ___
Kidney Perfusion
GFR diminishes with __
Age
What age is the peak of kidney function?
30 years old
What is Urea?
Bodily wastes
High blood urea nitrogen (BUN) is
Azotemia
What 3 things increase BUN
The kidney dysfunctions
High protein diet is consumed
Dehydration concentrate blood urea
Aldosterone
Increases Na retention from nephron tubules
Antidiuretic Hormone (ADH)
Increases water retention from nephron tubules
Indicators for Kidney function
Serum creatinine
BUN
Creatinine clearance
What is creatinine?
a breakdown product of muscle
What does Creatinine clearance require?
Blod sample
Urine sample
24-hour urine volume
A decrease in creatinine clearance indicate what?
Decrease in GFR
High serum creatinine indicates what?
Kidney dysfunction
Why is BUN not tested alone?
There can be variations in people who are more muscular or have a high protein diet
Cystoscopy
invasive scope into the urethra and bladder
Why is ultrasound used to examine kidney function?
Visualize amount of urine in bladder
Urinaylsis
If high positive leukocyte esterase indicates bladder/kidney infection
IVP
Intravenous Pyelogram - type of radioactive dye
What is IVP used to detect?
Kidney stones
Urine Culture looks for a certain amount of ___
Colony forming units - indicates bacteria in urine
Acute Kidney Injury (AKI)
An abrupt insult to the kidney that causes a rapid decrease in renal filtration function
What is the most common cause of AKI
Ischemia of the kidney > Necrosis
Prerenal dysfunction
Caused by decreased blood flow and perfusion to the kidney
Prerenal Dysfunction examples
Hypertension
Low CO
Hemorrhagic bleeding
Heart failure
Intrarenal dysfunction
Develops secondary to actual injuries to the kidneys itself
Intrarenal dysfunction examples
Trauma
Nephrotoxic drugs (NSAIDS)
Glomerulonephritis
Acute tubule necrosis
Postrenal dysfunction
Related to obstruction of urine flow from kidneys
Postrenal dysfunction examples
Kidney Stones
Prostate Gland Hyperplasia (PBH)
4 Phases of AKI
Initial Insult
Oliguria
Diuresis
Recovery