EBM lectures (both) Flashcards
project purpose includes
- method
- population
- setting, timeframe
SMART goal
- specific
- measurable
- attainable
- relevant
- time based
primary variable of interest that are essence of project
outcome variables
DV
exposures of interest, predictors of outcome, variables that define subgroups
predictor variables
IV
directly measure how a patient feels, functions or survives
clinically meaningful endpoints
laboratory measure or physical sign intended to be used a substitute for a clinically meaningful endpoint
surrogate endopoint
provides strong evidence of temporality
cohort study
forward directionality
participants are enrolled and followed forward in time to see if they develop the outcome of interest
cohort study
backwards directional study where participants are defined based on disease status
case control study
non directional study
exposure and outcome captured at the same time
cross sectional study
use groups of people, geographically based
ecologic study
most common study design to determine medical test performance
cross sectional
compilation of data from multiple studies to answer a study question that has been repeatedly addressed in literature
meta analysis
- allows for one individual to serve as their own control
- each individual receives both the intervention and control in sequential order
case crossover study
allows for unbiased assignment of study participants from one group to another
randomization
uses secondary data originally collected for a different purpose
nested case control
compare populations
ecologic study
assesses exposure and outcome at one point in time and does not involve assigning control groups
cross sectional
participants selected on the basis of a case, then matched to control group
case control
after the primary outcome is defined, what is the next step?
participant selection and study setting
conducts comprehensive study of literature to address a specific clinical question
systematic review